{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:02:43Z","timestamp":1791460963487,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F32 AI186297"],"award-info":[{"award-number":["F32 AI186297"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F31 AI172110"],"award-info":[{"award-number":["F31 AI172110"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI145941"],"award-info":[{"award-number":["R01 AI145941"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cellular Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The alveolins are a family of intermediate filament\u2010like proteins that form cytoskeletal structures in both free\u2010living and parasitic members of the alveolate kingdom. Despite their important functions, the alveolins\u2019 biochemical properties and organizing principles are still poorly understood. Here, we characterize four alveolins of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    , the deadliest malaria parasite, to understand how alveolin domains mediate protein\u2013protein interactions and highly specific recruitment to substructures of the cytoskeleton. Unexpectedly, we uncover variable dependence on alveolin domains for each substructure rather than an overarching mechanism. While\n                    <jats:italic>Pf<\/jats:italic>\n                    IMC1e requires 1f to be sequentially recruited to the basal complex,\n                    <jats:italic>Pf<\/jats:italic>\n                    IMC1c and\n                    <jats:italic>Pf<\/jats:italic>\n                    IMC1g do not require interactions with each other to localize properly to the inner membrane complex. Moreover, alveolin domains are not interchangeable\u2014they contain unique signatures for specialized localization. Finally, we identify a region outside the alveolin domain of\n                    <jats:italic>Pf<\/jats:italic>\n                    IMC1e that is important for basal complex recruitment. These results provide direct evidence that alveolin domains mediate both alveolin\u2013alveolin interactions and compartment\u2010specific localization.\n                  <\/jats:p>","DOI":"10.1155\/cmi\/4530231","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:58:53Z","timestamp":1751525933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Malaria Cytoskeletal Proteins Require Alveolin\u2013Alveolin Interactions for Differential Localization"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-461X","authenticated-orcid":false,"given":"Ana Karla","family":"Cepeda Diaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4653-8602","authenticated-orcid":false,"given":"Peter S.","family":"Back","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-3714","authenticated-orcid":false,"given":"Sreelakshmi K.","family":"Sreenivasamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-7271","authenticated-orcid":false,"given":"Jeffrey D.","family":"Dvorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.1.21-38.2002"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.099002"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200406068"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10214-z"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02020-18"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00289-4"},{"key":"e_1_2_10_7_2","volume-title":"The Toxoplasma Subpellicular Network Is Highly Interconnected and Defines Parasite Shape for Efficient Motility and Replication","author":"Back P. 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Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cmi\/4530231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cmi\/4530231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cmi\/4530231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:53:21Z","timestamp":1772981601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cmi\/4530231"}},"subtitle":["Recruitment and Organization of Alveolin 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