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As the prescription of these agents is rapidly increasing, clinicians will need to familiarize themselves with the potential adverse events associated with their use. Nausea, vomiting, and poor oral intake are known side effects of GLP\u20101 agonists. In elderly patients with diabetes and multiple comorbidities who are on complex medication regimens, semaglutide can lead to clinically significant dehydration at a rapid pace. We report a case of a patient developing dehydration leading to acute kidney failure with life\u2010threatening metformin\u2010induced lactic acidosis. Close clinical and laboratory monitoring is advised when initiating semaglutide treatment in combination with other diabetic medications, especially in elderly patients.<\/jats:p>","DOI":"10.1155\/crcc\/3478800","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:45:06Z","timestamp":1778946306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two Doses to ICU or When Lactate Equals Glucose: Life\u2010Threatening Lactic Acidosis due to Metformin After Initiation of Semaglutide"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1396-0437","authenticated-orcid":false,"given":"Zhanna","family":"Albany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gutteridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5107-3857","authenticated-orcid":false,"given":"Areeba","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30249-9"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2023.10.002"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.645563"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc13977"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0038-6"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004752"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12824"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30092-X"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30013-X"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.62347\/RYLN5360"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-010-9423-8"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.20213210S1139c"}],"container-title":["Case Reports in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crcc\/3478800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crcc\/3478800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crcc\/3478800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:45:08Z","timestamp":1778946308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crcc\/3478800"}},"subtitle":[],"editor":[{"given":"Lipi","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crcc\/3478800"],"URL":"https:\/\/doi.org\/10.1155\/crcc\/3478800","archive":["Portico"],"relation":{},"ISSN":["2090-6420","2090-6439"],"issn-type":[{"value":"2090-6420","type":"print"},{"value":"2090-6439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3478800"}}