{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:16:05Z","timestamp":1788344165599,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":244,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Pulmonary toxoplasmosis is a rare but potentially life\u2010threatening manifestation of\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    infection in immunocompetent individuals. Clinical presentation is often nonspecific and may mimic viral or atypical pneumonia, leading to delayed diagnosis. We report the case of a previously healthy 32\u2010year\u2010old man who presented with a mononucleosis\u2010like syndrome complicated by rapidly progressive hypoxemic respiratory failure requiring invasive mechanical ventilation. Initial evaluation revealed marked systemic inflammation, cytopenias, hyperferritinemia, and mixed\u2010pattern hepatitis. Chest computed tomography demonstrated bilateral consolidations, ground\u2010glass opacities, pleural effusions, and interstitial changes. Extensive microbiological and immunological investigations were initially unrevealing. Polymerase chain reaction (PCR) testing for\n                    <jats:italic>T. gondii<\/jats:italic>\n                    was positive in blood despite negative IgG serology and isolated IgM positivity, raising concern for potentially misleading serological findings. The diagnosis of pulmonary toxoplasmosis was subsequently confirmed by PCR detection of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    DNA in bronchoalveolar lavage fluid. Targeted treatment with trimethoprim\u2013sulfamethoxazole led to rapid clinical and biochemical improvement, allowing successful extubation after 6 days of mechanical ventilation and complete radiological resolution prior to discharge. This case highlights the diagnostic challenges of pulmonary toxoplasmosis in immunocompetent hosts and underscores the importance of molecular testing in critically ill patients with severe pneumonia and ambiguous serological findings.\n                  <\/jats:p>","DOI":"10.1155\/crcc\/7875906","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:38:33Z","timestamp":1788341913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Respiratory Failure due to Pulmonary Toxoplasmosis in an Immunocompetent Patient: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"given":"Mar\u00eda Jes\u00fas","family":"Ojeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-8767","authenticated-orcid":false,"given":"Leonardo","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6020-5387","authenticated-orcid":false,"given":"Rodrigo","family":"Kemeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2850-7012","authenticated-orcid":false,"given":"Pablo","family":"Regueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-5651","authenticated-orcid":false,"given":"Tomas","family":"Regueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05013-11"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/317471"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000496"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-017-1111-3"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-185"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.174-178.1997"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-9946202365019"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4037-4044.2002"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1081CP"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001379"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0589OC"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0550LE"}],"container-title":["Case Reports in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crcc\/7875906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crcc\/7875906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crcc\/7875906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:38:33Z","timestamp":1788341913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crcc\/7875906"}},"subtitle":[],"editor":[{"given":"Lipi","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crcc\/7875906"],"URL":"https:\/\/doi.org\/10.1155\/crcc\/7875906","archive":["Portico"],"relation":{},"ISSN":["2090-6420","2090-6439"],"issn-type":[{"value":"2090-6420","type":"print"},{"value":"2090-6439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7875906"}}