{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:43:55Z","timestamp":1782978235042,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\n                      The study is aimed at exploring the complex clinical scenario of a patient with systemic lupus erythematosus who developed a rare coinfection with\n                      <jats:italic>Listeria monocytogenes<\/jats:italic>\n                      and\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      . The rationale is to highlight the diagnostic and therapeutic challenges in managing such a case, particularly in the context of immunosuppression and the need for effective antimicrobial therapy. This case underscores the importance of advanced diagnostic techniques like metagenomic next\u2010generation sequencing in identifying coinfections and the critical balance required in treating both infections while managing the underlying autoimmune condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Concerns<\/jats:title>\n                    <jats:p>This case report presents a 58\u2010year\u2010old female patient who initially manifested thrombocytopenia and was diagnosed with SLE in an external hospital. After treatment, her condition did not improve. On the contrary, she developed a fever and a headache, and her disturbance of consciousness gradually worsened. The patient was admitted to our hospital with a suspected diagnosis of lupus encephalopathy and central nervous system infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnoses<\/jats:title>\n                    <jats:p>\n                      MRI plain scan showed linear enhancement shadows in the right temporal pole and bilateral cerebellar hemisphere regions on the fluid\u2010attenuated inversion recovery three\u2010dimensional volumetric fluid\u2010attenuated inversion recovery contrast\u2010enhanced scan. Subsequently, NGS of the cerebrospinal fluid detected\n                      <jats:italic>L. monocytogenes<\/jats:italic>\n                      and\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      , suggesting a possible mixed infectious meningitis caused by these two pathogens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>\n                      The patient underwent a comprehensive treatment regimen including anti\n                      <jats:italic>Listeria<\/jats:italic>\n                      and antituberculosis therapies. Unfortunately, this was followed by the development of liver failure and various other complications. In response, we administered interventions such as blood purification and liver support measures. Furthermore, we organized a multidisciplinary consultation to address the complex medical needs of the patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>Despite aggressive medical interventions, the patient\u2032s condition deteriorated. She developed multiorgan failure, which significantly impacted her prognosis. The patient\u2032s family elected to withdraw life\u2010sustaining treatment, and the patient passed away within 24\u2009h after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lessons<\/jats:title>\n                    <jats:p>This case underscores the importance of early and accurate diagnosis, particularly for immunocompromised patients with complex clinical presentations. Identifying mixed infections is crucial, and it also poses a significant challenge in selecting appropriate antimicrobial agents and conducting relevant tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crcc\/9615951","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:47:40Z","timestamp":1782974860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Meningitis with Possible Coinfection by\n                    <i>Listeria monocytogenes<\/i>\n                    and\n                    <i>Mycobacterium tuberculosis<\/i>\n                    (Detected by Metagenomic Next\u2010Generation Sequencing) and Literature 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