{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:49:03Z","timestamp":1782478143218,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":176,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital cytomegalovirus (CMV) infection is the most common intrauterine infection worldwide. Maternal primary infection is diagnosed with presence of IgM antibodies, detection of IgG with low avidity index, and\/or IgG seroconversion in sequential serum samples. We report the first case of a pregnant woman with persistent CMV IgM positivity without IgG seroconversion, which raises significant questions regarding immune response and fetal risk assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 39\u2010year\u2010old woman, with a history of ankylosing spondylitis and biologic immunosuppression, exhibited persistent CMV IgM positivity and high\u2010level viremia without IgG seroconversion over two years of fertility support follow\u2010up. During her pregnancy, CMV IgM remained positive with transient viremia. Fetal evaluations were normal, and CMV DNA was not detected in amniotic fluid. The infant was born healthy, and, to date, no neurodevelopmental changes have been identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores a rare immunological profile with significant implications for CMV diagnosis and fetal risk assessment. Persistent CMV IgM without IgG seroconversion, although rare, may occur in patients undergoing immunomodulatory therapies, complicating the interpretation of maternal and fetal risk. This scenario requires individualized care and a multidisciplinary approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/1322365","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:15:46Z","timestamp":1782476146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent CMV IgM Without IgG Seroconversion in an Immunomodulated Pregnant Woman: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-4814","authenticated-orcid":false,"given":"Francisco","family":"Vale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Magano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Alicerces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Trabucho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-765X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Lourinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Silva","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_2_10_3_2","unstructured":"Sociedade Portuguesa De Virologia Recomenda\u00e7\u00f5es Para O Diagn\u00f3stico Pr\u00e9-Natal Virol\u00f3gico 2025 https:\/\/www.spv.pt\/recomendacoes.php."},{"key":"e_1_2_10_4_2","volume-title":"Circular Normativa no 02\/DSMIA","author":"Dire\u00e7\u00e3o-Geral Da Sa\u00fade","year":"2006"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100892"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2123795"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2025-005724"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31868-7"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030396"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175006"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3857"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.662"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050694"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26128"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/1322365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/1322365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/1322365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:15:50Z","timestamp":1782476150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/1322365"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdi\/1322365"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/1322365","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1322365"}}