{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:47:30Z","timestamp":1770778050754,"version":"3.50.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Entamoeba histolytica<\/jats:italic>\n                    is an amebic protozoan that is often asymptomatic, with many patients being asymptomatic carriers. However, 10 percent of cases manifest with amebic dysentery and, less commonly, amebic liver abscesses. Amebic liver abscesses are the most common extraintestinal manifestation of\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    . Patients may remain asymptomatic for years before presenting with active infection. Treatment of\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    amebic abscesses with nitroimidazoles, such as metronidazole and tinidazole, is a long\u2010established approach that has remained unchanged since its discovery in the 1960s. However, given that this condition is known to be fatal without treatment, the outcome for a patient who cannot tolerate nitroimidazole therapy can be catastrophic. We present the case of a 54\u2010year\u2010old male who presented with what was initially thought to be a large, pyogenic liver abscess and who was started on standard empiric antibiotic therapy and percutaneous drainage. However, due to a lack of clinical response, his regimen was changed to eravacycline, a novel halogenated tetracycline, which led to a good response. Interestingly, the abscess was later discovered to be amebic in this patient, who had a low\u2010risk history for\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    infection. This case demonstrates a clinical response to eravacycline monotherapy in a patient with\n                    <jats:italic>E. histolytica<\/jats:italic>\n                    liver abscess. We re\u2010examine the history of tetracyclines in the treatment of parasitic infections and consider the new, more potent halogenated tetracyclines as a potential alternative to the current standard of care.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/1368034","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T13:38:28Z","timestamp":1770644308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Clinical Response of a Large Amebic Liver Abscess to Eravacycline Prior to Metronidazole Initiation: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-1584","authenticated-orcid":false,"given":"Jamal A.","family":"Anthony","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-352X","authenticated-orcid":false,"given":"Andrew","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8687-3111","authenticated-orcid":false,"given":"Lisa","family":"Pedroza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_7_1_2","volume-title":"Entamoeba histolytica Infection","author":"Chou A.","year":"2025"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i36.13157"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.4.713-729.2003"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cld.488"},{"key":"e_1_2_7_5_2","first-page":"2584","article-title":"Prognostic Markers in Amebic Liver Abscess: A Prospective Study","volume":"91","author":"Sharma M. P.","year":"1996","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx351"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017002025"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004886.pub2"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195407000-00002"},{"key":"e_1_2_7_10_2","first-page":"251","article-title":"Comparison Between the Efficacy of a Single Dose of Secnidazole With a 5-Day Course of Tetracycline and Clioquinol in the Treatment of Acute Intestinal Amoebiasis","volume":"4","author":"Soedin K.","year":"1985","journal-title":"Pharmatherapeutica"},{"key":"e_1_2_7_11_2","first-page":"99","article-title":"Therapeutic Trial of Four Amoebicide Regimes in Rural Zaire","volume":"82","author":"Masters D. K.","year":"1979","journal-title":"Journal of Tropical Medicine & Hygiene"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0545-8"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/1368034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/1368034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/1368034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:50:45Z","timestamp":1770720645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/1368034"}},"subtitle":[],"editor":[{"given":"Rajib","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdi\/1368034"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/1368034","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1368034"}}