{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:58:20Z","timestamp":1781693900920,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Mucosal leishmaniasis (ML) is a rare, destructive, and recurrent protozoal infection caused by\n                      <jats:italic>Leishmania<\/jats:italic>\n                      species, most commonly\n                      <jats:italic>Leishmania braziliensis<\/jats:italic>\n                      . ML can develop months to years after initial cutaneous leishmaniasis (CL) and may lead to severe mucosal destruction if untreated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      We present a case of a 48\u2010year\u2010old healthy male from Venezuela with prior CL treated with intravenous meglumine antimoniate who subsequently developed progressive nasal symptoms consistent with ML. Initial therapy with oral fluconazole was ineffective, but treatment with miltefosine led to symptom resolution. The patient underwent four\u2010staged reconstructive surgeries with ENT. Thirty\u2010eight months later, the patient developed recurrent symptoms, and biopsy confirmed infection with\n                      <jats:italic>L. braziliensis<\/jats:italic>\n                      . He was subsequently treated with intravenous amphotericin B, which led to clinical improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This case highlights the relapsing nature of ML, its potential for extensive mucosal damage, and the importance of a structured, long\u2010term care plan. This case in particular is unique given the extended delay before recurrence following miltefosine therapy. The high recurrence rate of\n                      <jats:italic>L. braziliensis<\/jats:italic>\n                      infections underscores the importance of vigilant long\u2010term follow\u2010up and consideration of systemic therapy. Multidisciplinary management is often necessary to optimize outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early recognition of ML, timely systemic therapy, structured multidisciplinary care, and adherence to a long\u2010term surveillance plan are critical to prevent mucosal destruction and manage relapses effectively. Extended surveillance may be warranted to detect late relapses in patients treated with newer or more effective agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/1784961","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:48:16Z","timestamp":1781693296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relapsing Nasal Septal Leishmaniasis: Lessons in Long\u2010Term Multidisciplinary Management Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9122-5667","authenticated-orcid":false,"given":"Emily","family":"Ehsan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellie","family":"Staab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Geelan-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hankins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"UpToDate Cutaneous Leishmaniasis: Clinical Manifestations and Diagnosis https:\/\/www.uptodate.com\/contents\/cutaneous-leishmaniasis-clinical-manifestations-and-diagnosis."},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw670"},{"key":"e_1_2_11_3_2","unstructured":"UpToDate Cutaneous Leishmaniasis: Treatment https:\/\/www.uptodate.com\/contents\/cutaneous-leishmaniasis-treatment."},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.10753"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30586"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21-0928"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03190.x"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010931"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2022.106512"},{"key":"e_1_2_11_10_2","first-page":"25","article-title":"Efficacy and Safety of Liposomal Amphotericin B (Ambisome) for Visceral Leishmaniasis in Endemic Developing Countries","volume":"76","author":"Berman J. D.","year":"1998","journal-title":"Bulletin of the World Health Organization"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/1784961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/1784961","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/1784961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:48:20Z","timestamp":1781693300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/1784961"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdi\/1784961"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/1784961","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1784961"}}