{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:00:21Z","timestamp":1775232021829,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dengue is endemic in the Maldives and remains a major public health concern in this small island nation of approximately half a million people. Genetic red blood cell disorders, particularly thalassemia, are common; however, the prevalence of other inherited disorders, such as glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency, remains poorly characterized. Despite this, sporadic cases of hemolytic anemia in G6PD deficient individuals have been reported. The presence of G6PD deficiency may alter the clinical course of acute dengue infection, as illustrated in the case presented, and require careful management to prevent complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 22\u2010year\u2010old male presented with fever, headache, nausea, vomiting, and jaundice, which rapidly progressed to include epistaxis and dark\u2010colored urine. Laboratory findings revealed leukopenia, thrombocytopenia, elevated unconjugated bilirubin, markedly reduced G6PD activity, and elevated creatine kinase levels. While the dengue NS1 antigen test was positive during acute illness, follow\u2010up serology at 8\u2009months remained negative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case depicts the potential for concurrent hemolysis and rhabdomyolysis in G6PD\u2010deficient patients with dengue in endemic settings. Clinicians should maintain a high index of suspicion for these complications in patients presenting with fever and jaundice, as early recognition through vigilant clinical observation may influence management and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/2341390","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:20:52Z","timestamp":1775229652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When Fever Turns Hemorrhagic in the Maldives: A Case Report of Dengue in a G6PD\u2010Deficient Young Adult With Hemolysis and Rhabdomyolysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-1164","authenticated-orcid":false,"given":"Rajib","family":"Dey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8173-0891","authenticated-orcid":false,"given":"Gunjan","family":"Khadka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuhufa","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Su","family":"Htun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Miqdhaadh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1665-3716","authenticated-orcid":false,"suffix":"Jr.","given":"Nestor","family":"Arce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-2765","authenticated-orcid":false,"given":"Wasin","family":"Matsee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakaykaew","family":"Charunwatthana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-6334","authenticated-orcid":false,"given":"Hisham","family":"Imad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0407"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/2224-3151.206886"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2023.08.001"},{"key":"e_1_2_13_4_2","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2026.2622217","article-title":"Dengue and Aging: Challenges and Opportunities in Prevention and Care. A Narrative Review","author":"Beccacece A.","year":"2026","journal-title":"Emergy Microbes Infection"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0332039"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jtm.12202"},{"key":"e_1_2_13_7_2","doi-asserted-by":"crossref","unstructured":"Sri Lanka Journal of Medicine 2019 28 Dengue Complicated by Acute Haemolysis Methaemoglobinemia Hepatitis and Rhabdomyolysis in A Patient with G6PD Deficiency","DOI":"10.4038\/sljm.v28i2.127"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000944"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0374"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.05.007"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-019-1204-y"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/reports7020045"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed6030152"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0343"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36379"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/2341390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/2341390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/2341390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:20:53Z","timestamp":1775229653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/2341390"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdi\/2341390"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/2341390","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2341390"}}