{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:04:15Z","timestamp":1772989455650,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Tick\u2010borne encephalitis (TBE), a zoonotic disease caused by the tick\u2010borne encephalitis virus (TBEV), usually manifests with a biphasic course with neurological involvement during its second phase. Extraneurological manifestations are rare but clinically relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case of a 77\u2010year\u2010old patient with suspected acute myocarditis associated with central European TBEV infection and summarize the literature on extraneurological TBEV manifestations through a systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The case of a 77\u2010year\u2010old patient with suspected acute myocarditis associated with central European TBEV infection is reported and discussed. Literature analysis identified 23 publications reporting extraneurological TBEV manifestations, including (peri)myocarditis, myositis, hematological abnormalities, and elevated transaminases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TBEV infection can be complicated by myocarditis and should therefore be considered in the differential diagnosis in areas where TBEV is endemic in a patient with risk factors for tick bites. Vaccination remains crucial for preventing TBEV infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/3051689","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:01:16Z","timestamp":1771650076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extraneurological Presentations of Tick\u2010Borne Encephalitis Virus: A Rare Case of TBEV\u2010Associated Myocarditis With Fever and Bicytopenia and a Systematic Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-2641","authenticated-orcid":false,"given":"Marco","family":"Seneghini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Lugano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha T.","family":"Maeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Garcia-Boy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-262X","authenticated-orcid":false,"given":"Carol","family":"Strahm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000672"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032921"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0081-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9062.308794"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parepi.2020.e00160"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2802.211661"},{"key":"e_1_2_11_7_2","first-page":"347","article-title":"[Hepatitis Caused by Tick-Borne Meningoencephalitis Virus (TBEV)--A Rare Clinical Manifestation Outside the Central Nervous System Involvement]","volume":"59","author":"Misi\u0107-Majerus L.","year":"2005","journal-title":"Acta Medica Croat Cas Hravatske Akad Med Znan"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.05.021"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008353"},{"key":"e_1_2_11_10_2","first-page":"275","article-title":"Thrombocytopenia, Leukopenia and Abnormal Liver Function Tests in the Initial Phase of Tick-Borne Encephalitis","volume":"282","author":"Lotric-Furlan S.","year":"1995","journal-title":"International Journal of Medical Microbiology"},{"key":"e_1_2_11_11_2","unstructured":"Extraneurological Presentations of Tick-borne Encephalitis Virus: A Rare Case of TBEV-Associated Myocarditis with Fever and Bicytopenia and a Systematic Literature Review 2023 https:\/\/www.readcube.com\/library\/9495da6f-251d-4637-b028-ef9574ff1257:183d84fa-80dd-4eb8-b9dc-95831f30c9d7."},{"key":"e_1_2_11_12_2","unstructured":"European Heart Journal Oxford Academic 2025 2025 ESC Guidelines for the Management of Myocarditis and Pericarditis"},{"key":"e_1_2_11_13_2","first-page":"803","article-title":"Cardiac Disease in Patients With Tick-Borne Encephalitis","volume":"18","author":"Tesarova-Magrova J.","year":"1966","journal-title":"Giornale di Malattie Infettive e Parassitarie"},{"key":"e_1_2_11_14_2","first-page":"514","article-title":"Ueber Einen Fall Mit Fruehsommermeningoencephalitis Mit Leberbeteiligung","volume":"78","author":"Hofbauer K.","year":"1966","journal-title":"Wiener Klinische Wochenschrift"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed7120434"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06058-6"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12017"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0834-7"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.040469"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2018.10.008"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.1999.0587"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.11.008"},{"key":"e_1_2_11_23_2","article-title":"[Agranulocytic Reaction in Tick-Borne Encephalitis]","volume":"63","author":"Mokrousov V. 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