{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:27:22Z","timestamp":1773782842394,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brucellosis is a globally significant zoonotic disease, but congenital brucellosis remains exceedingly rare. It is primarily transmitted transplacentally from an infected mother to the fetus, often presenting with nonspecific signs that mimic neonatal sepsis. The condition poses diagnostic and therapeutic challenges, particularly in endemic regions where early identification is crucial to improving neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      We report the case of a 19\u2010year\u2010old gravida 1, para 0 female with a history of treated\n                      <jats:italic>Brucella<\/jats:italic>\n                      infection at 12\u2009weeks of gestation. She experienced preterm premature rupture of membranes (PPROM) at 24\u2009weeks and 2\u2009days and delivered a female infant via spontaneous vaginal delivery. The neonate, weighing 725\u2009g at birth, presented with cyanosis, respiratory distress, and unstable vital signs. Initial workup suggested early onset sepsis, prompting empirical antibiotic therapy. However, on Day 7, blood cultures confirmed the presence of\n                      <jats:italic>Brucella melitensis<\/jats:italic>\n                      and\n                      <jats:italic>Brucella abortus<\/jats:italic>\n                      , establishing the diagnosis of congenital brucellosis. The neonate\u2019s clinical course was complicated by intraventricular hemorrhage, necrotizing enterocolitis, multiple episodes of sepsis, and cardiac arrests. Despite intensive medical management, including antimicrobial therapy with rifampicin and gentamicin, the infant succumbed to multiple organ failure on Day 39 of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case highlights the diagnostic challenges of congenital brucellosis and underscores the importance of considering\n                      <jats:italic>Brucella<\/jats:italic>\n                      infection in neonates presenting with unexplained sepsis, especially in endemic regions. Early recognition and targeted therapy are essential to improve neonatal outcomes. Enhanced screening protocols for pregnant women in high\u2010risk areas, coupled with heightened clinical suspicion in neonates with maternal brucellosis exposure, could facilitate timely diagnosis and treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/4095776","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:19:46Z","timestamp":1762229986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Brucellosis in an Extremely Preterm Infant: A Fatal Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9511-9131","authenticated-orcid":false,"given":"Muhammad","family":"Takhman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6771-193X","authenticated-orcid":false,"given":"Orabi","family":"Hajjeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2835-0429","authenticated-orcid":false,"given":"Moath","family":"Hattab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8028-503X","authenticated-orcid":false,"given":"Reem","family":"Shihab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeel","family":"Atout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabee","family":"Adwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoun A. T.","family":"Ibaideya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"599","article-title":"Congenital Brucellosis in a Preterm Neonate","volume":"42","author":"Mosayebi Z.","year":"2005","journal-title":"Indian Pediatrics"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.05.023"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2021.0015"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520975576"},{"key":"e_1_2_11_5_2","unstructured":"Al-AyyadhiN. H. Al-AwadhiS. S. Al-ShammariF. J. andHassanH. A. A Rare Congenital Brucellosis Re-Emerging in Kuwait: A Case Report 2023 https:\/\/www.gavinpublishers.com\/article\/view\/a-rare-congenital-brucellosis-re-emerging-in-kuwait-a-case-report."},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2022.04.009"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519838921"},{"key":"e_1_2_11_8_2","unstructured":"Yetmi\u015fE. Congenital Brucellos in a Premature Infant http:\/\/hnhtipdergisi.com\/jvi.aspx?un=HNHJ-78055."},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.79736"},{"key":"e_1_2_11_10_2","first-page":"272","article-title":"Brucella melitensis in Blood Cultures of Two Newborns Due to Exchange Transfusion","volume":"47","author":"Ak\u00e7aku\u015f M.","year":"2005","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0581-z"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2018.2280"},{"key":"e_1_2_11_13_2","first-page":"433","article-title":"Prematurity Due to Maternal Brucella Infection and Review of the Literature","volume":"55","author":"Ayd\u0131n B.","year":"2013","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984407"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00582-23"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/4095776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/4095776","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/4095776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:54:56Z","timestamp":1773770096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/4095776"}},"subtitle":[],"editor":[{"given":"Dawei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdi\/4095776"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/4095776","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4095776"}}