{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:27:20Z","timestamp":1773782840916,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":359,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Actinomycosis is a rare bacterial infection caused by\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    species, most commonly affecting the cervicofacial region. Posterior skull base involvement is extremely uncommon. We report a case of actinomycosis in a 44\u2010year\u2010old male with a 10\u2010year history of chronic hepatitis B on tenofovir therapy, who presented with a 3\u2010month history of progressive right\u2010sided neck swelling, pain, occipital headaches, and a 10\u2009kg weight loss. The patient initially experienced a sore throat and neck discomfort, partially relieved by medication, but gradually developed a foreign body sensation in the retropharynx and painful swelling in the lateral neck and behind the right ear, accompanied by fever and chills. Physical examination revealed swelling, erythema, warmth over the right lateral neck, and neck stiffness. MRI showed an ill\u2010defined infiltrative lesion at the posterior skull base, involving the right occipital bone and upper cervical vertebrae, extending into adjacent soft tissues. Biopsy of the lesion demonstrated filamentous organisms with sulfur granules amid a mixed inflammatory response, confirming actinomycosis. The patient was treated with intravenous ceftriaxone followed by oral amoxicillin, along with surgical drainage from the right posterior cervical region. At the 11\u2009week follow\u2010up, he showed significant clinical improvement, with continued long\u2010term antibiotics due to bone involvement. This case highlights the diagnostic challenges posed by atypical presentations of actinomycosis, particularly in patients with predisposing conditions such as chronic infections. Unlike typical cervicofacial actinomycosis, this patient lacked classical features such as discharging sinuses or lymphadenopathy. Recognition of sulfur granules in biopsy specimens was pivotal for diagnosis. Early diagnosis, prolonged high\u2010dose antibiotic therapy, and surgical intervention when needed are crucial to achieving favorable outcomes. Clinicians should maintain a high index of suspicion for actinomycosis in patients presenting with unexplained neck masses and skull base lesions.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/4580275","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T15:19:17Z","timestamp":1766762357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orocervical Actinomycosis in a Patient With Neck Swelling and Occipital Headache: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-8648","authenticated-orcid":false,"given":"Mehran","family":"Frouzanian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-8844","authenticated-orcid":false,"given":"Ahmad","family":"Alikhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-7322","authenticated-orcid":false,"given":"Amirsaleh","family":"Abdollahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68533"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418808541"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2021.e01215"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/smj.0b013e3181864c1f"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/ams.ams_176_18"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199810000-00118"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s39601"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19124"},{"key":"e_1_2_11_9_2","volume-title":"Actinomycosis","author":"Sharma S.","year":"2024"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23477"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/spi.2001.95.1.0132"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199905)21:3<264::AID-HED12>3.0.CO;2-Y"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14934"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1079-2104(97)90313-9"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0213-005x(02)72741-9"},{"key":"e_1_2_11_16_2","first-page":"239","article-title":"Cervicofacial Actinomycosis: Two Case Reports","volume":"119","author":"Mettler S.","year":"2009","journal-title":"Schweizer Monatsschrift fur Zahnmedizin = Revue Mensuelle Suisse D\u2019odonto-Stomatologie = Rivista Mensile Svizzera di Odontologia e Stomatologia"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000112418"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/4580275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/4580275","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/4580275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:54:55Z","timestamp":1773770095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/4580275"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdi\/4580275"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/4580275","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4580275"}}