{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:07:19Z","timestamp":1774566439661,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Lyme carditis is a complication occurring in 1%\u20135% of Lyme disease infections. It can lead to life\u2010threatening cardiac conduction abnormalities. Treatment with antibiotics may trigger the Jarisch\u2013Herxheimer reaction (JHR), an acute inflammatory response to spirochetal lysis. Here, we present a 32\u2010year\u2010old postpartum female with complete heart block and disseminated erythema migrans who developed JHR within hours of ceftriaxone initiation, requiring vasopressor support. Hemodynamic instability resolved within 24\u2009h, with subsequent normalization of cardiac conduction within 72\u2009h. This case highlights the importance of recognizing JHR, distinguishing it from allergic reactions and septic shock, and avoiding unnecessary antibiotic discontinuation.<\/jats:p>","DOI":"10.1155\/crdi\/5599926","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:32:28Z","timestamp":1772969548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Jarisch\u2013Herxheimer Reaction After Ceftriaxone Initiation for Lyme Carditis in Postpartum Female"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9217-6137","authenticated-orcid":false,"given":"Emily","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-6719","authenticated-orcid":false,"given":"Sunam","family":"Sujanani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-5434","authenticated-orcid":false,"given":"Ammara","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29661"},{"key":"e_1_2_7_2_2","volume-title":"Signs and Symptoms of Untreated Lyme Disease","author":"Centers for Disease Control and Prevention","year":"2024"},{"key":"e_1_2_7_3_2","volume-title":"Lyme Carditis","author":"Rivera O. 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