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This case report details a 47\u2010year\u2010old Iranian man who had recently returned from Jakarta, Indonesia, presenting with fever, diarrhea, vomiting, and myalgia during the COVID\u201019 outbreak. Despite initial misdiagnoses, dengue fever was confirmed through polymerase chain reaction (PCR) testing. Moreover, the serological analysis using enzyme\u2010linked immunosorbent assay (ELISA) further demonstrated the presence of both IgM and IgG antibodies against the dengue virus. Initially, the patient\u2019s symptoms overlapped with COVID\u201019 and gastrointestinal infections, complicating the diagnosis. The management included supportive care, precautions against bleeding, fluid therapy, and empirical antibiotics due to suspected coinfections. This case highlights the importance of considering travel history and the possibility of nonendemic diseases in the differential diagnosis of febrile illnesses of unknown origin (FUO), particularly during concurrent outbreaks. Comprehensive history\u2010taking and rigorous diagnostic evaluation are essential in such cases.<\/jats:p>","DOI":"10.1155\/crdi\/5742576","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:51:42Z","timestamp":1741683102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis and Management of Dengue Fever in a Nonendemic Country: Lessons From an Acute Febrile Illness in Iran During the COVID\u201019 Outbreak"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-5256","authenticated-orcid":false,"given":"Kimia","family":"Mozahheb Yousefi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7078-4146","authenticated-orcid":false,"given":"Solaleh","family":"Aminian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-9982","authenticated-orcid":false,"given":"Masoud","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-5971","authenticated-orcid":false,"given":"Sara","family":"Minaeian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-1116","authenticated-orcid":false,"given":"Azadeh","family":"Laali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.03.007"},{"key":"e_1_2_11_2_2","unstructured":"Dengue- Global Situation 2022 https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2023-DON498#:~:text=Inparticular%2CIndia%2CIndonesia%2C largernumberofdenguecases."},{"key":"e_1_2_11_3_2","unstructured":"Dengue Worldwide Overview [Internet]. 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