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Silver\u2013Russell syndrome, also a rare genetic condition, involves intrauterine growth restriction and multiple metabolic and physical abnormalities that could potentially worsen prognosis after severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. This study analyzed five hospitalized patients in Brazil, two with Berardinelli\u2013Seip syndrome and three with Silver\u2013Russell syndrome, with confirmed COVID\u201019. The results showed that most patients presented respiratory symptoms and peripheral oxygen saturation below 95% at admission. Among the cases, two required intensive care and two required noninvasive ventilatory support. Four patients were discharged, while one 19\u2010year\u2010old patient with Berardinelli\u2013Seip syndrome, who had multiple comorbidities and was unvaccinated, died. Symptom onset preceded hospitalization by 2\u20138\u2009days in Berardinelli\u2013Seip and 2\u20137\u2009days in Silver\u2013Russell patients. Time from symptom onset to outcome ranged from 6 to 10\u2009days. Hospital stays were short (2\u20136\u2009days). No Berardinelli\u2013Seip patient required intensive care unit admission; two Silver\u2013Russell patients required brief intensive care unit stays. Overall progression remained under 2\u2009weeks. The study did not identify a consistent association between COVID\u201019 severity and the presence of these two syndromes, although regular multidisciplinary follow\u2010up may have contributed to favorable outcomes in patients with Silver\u2013Russell syndrome. Despite diagnostic and data\u2010source limitations, the findings suggest that these rare conditions were not uniformly associated with poor outcomes, contrary to initial expectations. Further studies with larger cohorts are needed to clarify the interaction between rare diseases and COVID\u201019, improve risk stratification, and support clinical management in future public health emergencies.<\/jats:p>","DOI":"10.1155\/crdi\/5881408","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:32:15Z","timestamp":1781688735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patients With Berardinelli\u2013Seip and Silver\u2013Russell Syndromes Hospitalized due to Coronavirus Disease (COVID)\u201019 in Brazil: A Four\u2010Year Case Report Profile"],"prefix":"10.1155","volume":"2026","author":[{"given":"Luiz Felipe Azevedo","family":"Marques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriele Evelyn Ferreira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Teixeira","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Silva","family":"Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Santiago dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-4234","authenticated-orcid":false,"given":"Fernando Augusto Lima","family":"Marson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_12_1_2","unstructured":"World Health Organization (WHO) https:\/\/www.who.int\/."},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13240"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-022-02468-3"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2023.04.001"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40615-021-01031-6"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_162_23"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2023-012581"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2020.1786964"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33314-9"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.70024"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.13214"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20196863"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.2196\/48430"},{"key":"e_1_2_12_14_2","volume-title":"StatPearls","author":"Quinn K.","year":"2024"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2021.104075"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00680-1"},{"key":"e_1_2_12_17_2","volume-title":"GeneReviews\u00ae","author":"Saal H. 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