{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:59:55Z","timestamp":1790247595677,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":266,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2021-11060- FY21"],"award-info":[{"award-number":["200-2021-11060- FY21"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018450","name":"Wisconsin Department of Health Services","doi-asserted-by":"publisher","award":["435100-A24-ELCProjE-00"],"award-info":[{"award-number":["435100-A24-ELCProjE-00"]}],"id":[{"id":"10.13039\/100018450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immunocompromised (IC) individuals are at an increased risk for persistent SARS\u2010CoV\u20102 infections and can develop new viral mutations and lineages not seen in the community. In this case report, a persistent SARS\u2010CoV\u20102 infection (330\u2009days) in an IC patient is examined for viral mutations and mutations associated with cryptic lineages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>The patient was followed up in a longitudinal study examining persistent SARS\u2010CoV\u20102 in IC patients. The patient provided stool and nasal swab samples biweekly until 28\u2009days postenrollment, then monthly, and then quarterly after 12\u2009months post enrollment until the participant was no longer positive for SARS\u2010CoV\u20102. Staff performed RT\u2010qPCR and viral sequencing on the samples. Viral mutations from the XBK lineage were already present in the initial sample. By the end of the infection period, there were 40 fixed consensus changes from XBK of which two mutations were typical for cryptic lineages. Mutations increased steadily over time, with most mutations fixed by day 253, including the cryptic typical mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates the potential for persistent SARS\u2010CoV\u20102 infections to develop mutations and lineages in IC patients and highlights the need for continued SARS\u2010CoV\u20102 monitoring and treatment in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/6154094","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:04:36Z","timestamp":1790244276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Describing a Persistent SARS\u2010CoV\u20102 Infection Outcomes and Mutations Associated With B\u2010Cell Deficiency: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5365-2059","authenticated-orcid":false,"given":"Rana","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3357-5086","authenticated-orcid":false,"given":"Alex","family":"Shipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-1601","authenticated-orcid":false,"given":"Andrew","family":"Lail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-4935","authenticated-orcid":false,"given":"Isla","family":"Emmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-4788","authenticated-orcid":false,"given":"William","family":"Vuyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-8229","authenticated-orcid":false,"given":"Nicholas","family":"Minor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6708-7288","authenticated-orcid":false,"given":"Taylor","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-7215","authenticated-orcid":false,"given":"Angela","family":"Gifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9472-6026","authenticated-orcid":false,"given":"Nancy","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-470X","authenticated-orcid":false,"given":"David H.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2789-7503","authenticated-orcid":false,"given":"Jacqueline","family":"Garonzik-Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-6332","authenticated-orcid":false,"given":"Jeannina","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.731643"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2018.10.015"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004086"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.03.016"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.42006"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2666-5247(23)00336-1"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2025.04.004"},{"key":"e_1_2_10_8_2","doi-asserted-by":"crossref","unstructured":"MohamedR. 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