{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:13:28Z","timestamp":1783430008175,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":187,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Burkholderia cenocepacia<\/jats:italic>\n                    , a member of the\n                    <jats:italic>Burkholderia cepacia<\/jats:italic>\n                    complex (BCC), is an opportunistic, intrinsically multidrug\u2010resistant Gram\u2010negative bacillus most commonly associated with nosocomial outbreaks and chronic pulmonary infection in patients with cystic fibrosis. Endocarditis caused by\n                    <jats:italic>B. cenocepacia<\/jats:italic>\n                    is extremely rare and has been reported mainly in intravenous drug users or in association with prosthetic valves. We report a fatal case of native mitral valve infective endocarditis caused by\n                    <jats:italic>B. cenocepaci<\/jats:italic>\n                    a in a patient with end\u2010stage renal disease (ESRD) receiving maintenance hemodialysis. A 50\u2010year\u2010old woman with diabetes mellitus, hypertension, and ESRD on hemodialysis had recently been treated for\n                    <jats:italic>B. cenocepacia<\/jats:italic>\n                    bacteremia, identified by MALDI\u2010TOF MS, with a 2\u2010week course of intravenous ceftazidime. During the same admission, thrombosis of her arteriovenous fistula necessitated placement of a central venous dialysis catheter. She represented shortly after discharge with altered mental status. Blood cultures obtained from both peripheral and central sites again yielded Gram\u2010negative bacilli, with differential time to positivity suggesting a catheter\u2010related source. The organism was identified as\n                    <jats:italic>B. cenocepacia<\/jats:italic>\n                    by MALDI\u2010TOF mass spectrometry. Transthoracic echocardiography demonstrated a mobile mitral valve vegetation measuring 1.6\u2009\u00d7\u20090.9\u2009cm. Given extensive comorbidities and poor surgical candidacy, care was transitioned to palliation and the patient died during hospitalization. This case highlights the potential for\n                    <jats:italic>B. cenocepacia<\/jats:italic>\n                    to cause invasive endocardial infection in hemodialysis patients with indwelling central venous catheters.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/6619649","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:13:31Z","timestamp":1783426411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catheter\u2010Associated\n                    <i>Burkholderia cenocepacia<\/i>\n                    Infective Endocarditis in a Patient Receiving Maintenance Hemodialysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2584-011X","authenticated-orcid":false,"given":"Zhong Xhen","family":"Khor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Yee","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Zanariah Zainol","family":"Abidin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Soon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1086\/519177"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00139-19"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03960-2"},{"key":"e_1_2_12_4_2","volume-title":"CLSI M100: Performance Standards for Antimicrobial Susceptibility Testing","author":"Clinical and Laboratory Standards Institute","year":"2025"},{"key":"e_1_2_12_5_2","first-page":"271","article-title":"Fatal Burkholderia cepacia Prosthetic Valve Endocarditis","volume":"14","author":"Aggarwal N.","year":"2005","journal-title":"Journal of Heart Valve Disease"},{"key":"e_1_2_12_6_2","article-title":"Late Prosthetic Valve Endocarditis Caused by Burkholderia cepacia and Candida dubliniensis: The First Reported Case in the Medical Literature","volume":"9","author":"Saaraswat V.","year":"2009","journal-title":"The Internet Journal of Cardiology"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-114"},{"key":"e_1_2_12_8_2","first-page":"84","article-title":"A Case of Tricuspid Valve Endocarditis due to Burkholderia cepacia Complex","volume":"124","author":"Williamson D. A.","year":"2011","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.17727\/JMSR.2013\/1-005"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.5114\/kitp.2017.70535"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmmcr.0.005143"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0000000000000708"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6403943"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.55636\/ppid2010007"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.71548"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2024.102431"},{"key":"e_1_2_12_17_2","first-page":"23","article-title":"Burkholderia cepacia: A Rare Source of Endocarditis","volume":"107","author":"Gonzalez J. M.","year":"2024","journal-title":"Rhode Island Medical Journal"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.89793"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14080774"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-26712-8"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/6619649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/6619649","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/6619649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:13:33Z","timestamp":1783426413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/6619649"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdi\/6619649"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/6619649","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6619649"}}