{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:27:34Z","timestamp":1773782854219,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":332,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated liver and spleen involvement of tuberculosis (TB) is a rare presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 60\u2010year\u2010old male patient from Bahir Dar City in the Amhara Region of Ethiopia presented with a 4\u2010month history of low\u2010grade fever, significant weight loss, drenching night sweats, poor appetite, exertional shortness of breath, and easy fatigability. Two weeks before his presentation, all symptoms worsened, and the patient started to experience left upper quadrant (LUQ) abdominal pain with a dragging sensation. Abdominal ultrasound showed hepatosplenomegaly with a linear hypoechoic area seen at the upper pole of the spleen, likely infarctions, and periportal lymphadenomegaly was visible. An abdominal CT scan showed a subcapsular hematoma on the upper pole of the spleen. After carefully ruling out both infectious and noninfectious differential diagnoses, we considered extrapulmonary tuberculosis and decided to initiate an antituberculosis trial. Extrapulmonary TB (hepatosplenic TB) was considered, and anti\u2010TB medications were started. On his 6\u2010month follow\u2010up and evaluation, his symptoms were improved with normal physical findings and normal investigation findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even though isolated hepatosplenic TB is a rare condition, it has to be considered especially in low socioeconomic communities after excluding other alternative diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdi\/6629614","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T08:34:57Z","timestamp":1764405297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Diagnosis of Tuberculosis With Atypical Manifestations Involving the Liver and Spleen With Spontaneous Subscapular Hematoma in a Resource\u2010Limited Setting: A Case Report and Review of Literature"],"prefix":"10.1155","volume":"2025","author":[{"given":"Addisu Assfaw","family":"Ayen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abere","family":"Genetu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7193-4881","authenticated-orcid":false,"given":"Bekalu Mekonen","family":"Belay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengistu Melak","family":"Fekadie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-0070","authenticated-orcid":false,"given":"Belayneh Dessie","family":"Kassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273429"},{"key":"e_1_2_14_2_2","volume-title":"Global Tuberculosis Report","author":"WHO","year":"2021"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.11.003"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)32038-1"},{"key":"e_1_2_14_5_2","article-title":"Clinical Diagnosis of Tuberculosis with Atypicalmanifestations Involving Liver, and Spleen Withspontaneous Subscapular Hematoma: a Casereport and Review of Literature","volume":"1","author":"Mekonen Belay B.","year":"2024","journal-title":"Research Square"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-63-755-902"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870170804"},{"key":"e_1_2_14_8_2","first-page":"1","article-title":"Ravindra and Santosh Isolated Tuberculosis of Liver & Spleen: a Rare Presentation","volume":"6","author":"Zubin P. D. S.","year":"2020","journal-title":"Clinical Case Reports Revision"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15926"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8247"},{"key":"e_1_2_14_11_2","first-page":"328","article-title":"Isolated Hepatosplenic Tuberculosis","volume":"7","author":"Kumar V. P. D.","year":"2008","journal-title":"Hepatobiliary and Pancreatic Diseases International"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gov058"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omaa092"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/6629614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/6629614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/6629614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:55:02Z","timestamp":1773770102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/6629614"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdi\/6629614"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/6629614","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6629614"}}