{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:20:19Z","timestamp":1789154419856,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":87,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Cefepime, a fourth\u2010generation cephalosporin, is widely used in the treatment of infections caused by resistant Gram\u2010negative bacteria especially\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , or in severe infections, septic shock, and infections in immunocompromised patients. As it crosses the blood\u2013brain barrier, it can cause neurotoxicity which has mostly been reported in patients with impaired renal function. Patients can present with drowsiness, confusion, delirium, agitation, stupor, or coma, and sometimes with generalized myoclonus and seizures within two to six days after starting the antibiotic. This is a rare case report where a patient with intact kidney function presented with confusion and incoherence. After excluding the possible causes for encephalopathy, cefepime\u2010induced encephalopathy was diagnosed and the patient gradually improved after discontinuing the medication. This case is an unusual presentation of symptoms in a patient with normal kidney function, which necessitates further studies to establish other potential risk factors of cefepime\u2010induced neurotoxicity.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/6650287","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T06:49:41Z","timestamp":1743230981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cefepime\u2010Induced Encephalopathy in a Patient With Uncompromised Renal Function: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4630-4667","authenticated-orcid":false,"given":"Aayusha","family":"Dhakal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozone","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2011.03.009"},{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","unstructured":"Journal of Anaesthesia and Critical Care Reports 2020 6 Cephalosporins: A Friend or Foe? an Uncommon Cause for Encephalopathy: A Case Report","DOI":"10.13107\/jaccr.2020.v06i02.150"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2011.08.002"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03991.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.9.2265"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9268"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2013.878032"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40980"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omw042"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12502"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/23247096241259534"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.03.018"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx170"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1856-1"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12795"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/6650287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/6650287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/6650287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:54:38Z","timestamp":1773770078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/6650287"}},"subtitle":[],"editor":[{"given":"Larry M.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdi\/6650287"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/6650287","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6650287"}}