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This case report provides a summary of a 48\u2010year\u2010old male who presented to the Emergency Department of the University of Ghana Medical Centre with syncope and hemodynamic instability one week after receiving a yellow fever vaccine. A diagnosis of an atraumatic splenic rupture was eventually confirmed by imaging, and a splenectomy was done. This report aims to provide valuable insights into the recognition and management of atraumatic splenic rupture, a potential adverse event associated with the yellow\u2010fever vaccine. It also highlights the importance of prompt diagnosis and timely intervention in such life\u2010threatening cases.<\/jats:p>","DOI":"10.1155\/crdi\/7286972","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:26:36Z","timestamp":1760419596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Yellow Fever Vaccine\u2013Associated Viscerotropic Disease: A Unique Case of Atraumatic Splenic Rupture"],"prefix":"10.1155","volume":"2025","author":[{"given":"Eadbert","family":"Nortey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6469-0286","authenticated-orcid":false,"given":"Edmund M.","family":"Bediako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3024-067X","authenticated-orcid":false,"given":"Geraldine K.","family":"Mould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Mills-Annoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame","family":"Ekremet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Kyei-Baffour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ama","family":"Ekem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemima C. 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