{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:58:24Z","timestamp":1790686704016,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":271,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Clostridioides difficile<\/jats:italic>\n                    infection (CDI) remains a major clinical challenge, particularly when it is refractory or recurrent. We describe a 68\u2010year\u2010old woman with systemic lupus erythematosus and other comorbidities who developed fulminant refractory CDI, characterized by ileus and persistent symptoms despite a course of oral vancomycin. She presented with abdominal pain, bilious vomiting, and high\u2010volume diarrhea. Stool testing detected\n                    <jats:italic>C. difficile<\/jats:italic>\n                    toxins A and B, and imaging showed bowel dilatation, mucosal thickening, and lymphadenopathy. Despite 18\u2009days of oral vancomycin and intravenous metronidazole, she showed no clinical improvement. A single fecal microbiota transplantation (FMT) was therefore performed as rescue therapy. Diarrhea resolved completely within 3\u2009days, with no CDI recurrence or FMT\u2010related adverse events during 12\u2009months of follow\u2010up. This case illustrates the potential role of FMT as rescue therapy for fulminant refractory CDI in selected immunocompromised patients. Careful donor screening and close clinical monitoring remain essential, and further research is needed to define the long\u2010term safety of FMT in patients with autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/7694915","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:25:07Z","timestamp":1790684707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fecal Microbiota Transplantation as a Rescue Therapy for Refractory\n                    <i>Clostridioides difficile<\/i>\n                    Infection in a Patient With Lupus"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-9341","authenticated-orcid":false,"given":"Miguel Alejandro","family":"Pinz\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-6605","authenticated-orcid":false,"given":"Juan Felipe","family":"Betancur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0879-5604","authenticated-orcid":false,"given":"Andrea Paola Sierra","family":"Bola\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3213-9376","authenticated-orcid":false,"given":"Julio Andr\u00e9s","family":"Boada-Garnica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5356-4525","authenticated-orcid":false,"given":"Juan Felipe","family":"Llano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-9620","authenticated-orcid":false,"given":"Beatriz","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v16.i1.100560"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.190224.msl"},{"key":"e_1_2_12_3_2","first-page":"202","article-title":"Opportunistic Infections Mimicking Gastrointestinal Vasculitis in Systemic Lupus Erythematosus","volume":"13","author":"Diep J. T.","year":"2007","journal-title":"Journal of Clinical Rheumatology"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0000773376.35387.0f"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1701233"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.4037\/aacnacc2016703"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319548"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.01.008"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.08.027"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ipc.0000000000000338"},{"key":"e_1_2_12_11_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.24017\/science.2024.2.6","article-title":"Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions","volume":"9","author":"Qadir S. A.","year":"2024","journal-title":"Kurdistan J Appl Res"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/0100-6991e-20181609"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/7694915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdi\/7694915","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdi\/7694915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:25:08Z","timestamp":1790684708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdi\/7694915"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdi\/7694915"],"URL":"https:\/\/doi.org\/10.1155\/crdi\/7694915","archive":["Portico"],"relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7694915"}}