{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:06:24Z","timestamp":1779087984338,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":136,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Scedosporium apiospermum<\/jats:italic>\n                    is an emerging cause of invasive mold infection in immunocompromised hosts, often with central nervous system involvement and limited susceptibility to amphotericin B. We describe a 36\u2010year\u2010old lung transplant recipient who presented with fever, meningismus, and multiple enhancing brain lesions nine months post\u2010transplant. Cerebrospinal fluid studies, including metagenomic next\u2010generation sequencing (mNGS), were negative. Cardiac imaging revealed a pedunculated right ventricular septal mass, and plasma cell\u2010free DNA (cfDNA) testing (Karius) identified\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    . Subsequent brain biopsy and thrombectomy confirmed the diagnosis by histopathology and culture. Following surgical removal of the cardiac mass and treatment with voriconazole, the patient improved with near resolution of brain lesions. This case highlights disseminated\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    endocarditis diagnosed by plasma cfDNA despite negative CSF mNGS, underscoring that site\u2010specific mNGS may be falsely negative in compartmentalized infections. Plasma cfDNA testing can complement conventional and tissue\u2010based diagnostics for early detection of disseminated mold infections in transplant recipients.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/8041837","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:08:01Z","timestamp":1779084481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Scedosporium apiospermum<\/i>\n                    Infective Endocarditis With Brain Abscesses in a Lung Transplant Recipient: Review of the Literature and Evaluating the Use of Next\u2010Generation Sequencing"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4933-495X","authenticated-orcid":false,"given":"Emily","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-7383","authenticated-orcid":false,"given":"Julie","family":"England","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Jagadeesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2026.117347"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/426445"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/375822"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqab070"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.05910-11"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(21)00203-6"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13398"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnma.2024.01.012"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1045353"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.07.056"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/smj.0b013e3181a0b01c"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.07.010"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0255-0857(21)02535-4"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2002.0960"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/pl00015028"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.5.858"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.6.993"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00447020"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(80)80021-0"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.55.647.629"},{"key":"e_1_2_10_21_2","first-page":"1250","article-title":"Petriellidium Boydii (Allescheria Boydii) Endocarditis Associated With Porcine Valve Replacement","volume":"117","author":"Roberts F. 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