{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:33:57Z","timestamp":1788878037718,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Central nervous system (CNS) tuberculosis (TB) is a severe manifestation of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (MTB) infection, characterized by high mortality. Contezolid, a novel oxazolidinone antibiotic, exhibits in vitro activity against MTB and may offer a safety advantage over linezolid, a first\u2010generation oxazolidinone frequently linked to myelosuppression and neuropathy. Clinical data on contezolid in CNS tuberculosis remain scarce. We report a middle\u2010aged man with chronic renal allograft dysfunction who was receiving long\u2010term hemodialysis and subsequently developed severe CNS TB complicated by multiple coinfections, diabetes mellitus, and pancytopenia. An individualized multidrug regimen that included contezolid was successfully employed, suggesting its potential utility in complex CNS TB. This report highlights therapeutic considerations for similar patients and underscores the need for further research on the role of contezolid in TB treatment.\n                  <\/jats:p>","DOI":"10.1155\/crdi\/8814569","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:20:08Z","timestamp":1754749208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of Tuberculous Meningitis With Contezolid in a Patient With Complex Comorbidities: A Case Report and Literature 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Pharmacokinetic\/Pharmacodynamic Analysis","volume":"14","author":"Wu J.","year":"2023","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.03.020"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S413452"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S465350"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S461785"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119430"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01576-0"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm401931e"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106875"},{"key":"e_1_2_11_21_2","article-title":"Novel Oxazolidinones Harbor Potent In Vitro Activity Against the Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis in China","volume":"9","author":"Wang C.","year":"2022","journal-title":"Frontiers of Medicine"},{"key":"e_1_2_11_22_2","article-title":"Case Report: Successful Treatment With Contezolid in a Patient With Tuberculous Meningitis Who Was Intolerant to Linezolid","volume":"10","author":"Xu Z.","year":"2023","journal-title":"Frontiers of Medicine"}],"container-title":["Case Reports in Infectious 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