{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:22:41Z","timestamp":1773523361131,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":359,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Photosensitivity dermatitis is a multifactorial dermatologic condition characterized by an exaggerated cutaneous response to ultraviolet (UV) radiation, often exacerbated by exogenous agents, particularly photosensitizing medications. The pathophysiology involves direct phototoxic or immune\u2010mediated photoallergic mechanisms, leading to inflammatory skin reactions upon UV exposure. In individuals with vitiligo, the absence of melanocytes in depigmented areas significantly diminishes photoprotective mechanisms, rendering these regions highly susceptible to UV\u2010induced damage. Consequently, vitiliginous skin is inherently more vulnerable to photo\u2010induced inflammation and cutaneous injury. We report a 54\u2010year\u2010old man with generalized vitiligo who developed erythematous papules confined to sun\u2010exposed depigmented skin. The clinical course suggested a medication\u2010induced phototoxic reaction, likely potentiated by the patient\u2019s underlying lack of cutaneous melanin. This case highlights the need to recognize drug\u2010induced photosensitivity in vitiligo and understand how UV vulnerability and photosensitizing medications interact.<\/jats:p>","DOI":"10.1155\/crdm\/4302190","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:22:48Z","timestamp":1766748168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug\u2010Induced Phototoxicity in Vitiligo: The Role of Hydrochlorothiazide in Photosensitivity Dermatitis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5794-3124","authenticated-orcid":false,"given":"Andres D.","family":"Parga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-7864","authenticated-orcid":false,"given":"Celina","family":"Dubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7912-0233","authenticated-orcid":false,"given":"Donald","family":"Rudikoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.876695"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14314"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071537"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080723"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2004)079<0211:rcrqyf>2.0.co;2"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00226.x"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060936"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094642"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111429"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3744"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0323-7"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.15570\/actaapa.2020.3"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/4302190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdm\/4302190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/4302190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:53:56Z","timestamp":1772981636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdm\/4302190"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdm\/4302190"],"URL":"https:\/\/doi.org\/10.1155\/crdm\/4302190","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4302190"}}