{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:15:47Z","timestamp":1772993747247,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Recessive dystrophic epidermolysis bullosa (RDEB) belongs to a rare group of inherited dermatoses, which are characterised by mucosal and cutaneous fragility. Cutaneous squamous cell carcinoma (CSCC) is a common complication of RDEB. In the severe subtype of RDEB (RDEB\u2010S), CSCC is observed in 90% of the patients by 55\u2009years. CSCC in patients with RDEB follows an aggressive course with the median survival rate of 2.4\u2009years. We report the case of a 51\u2010year\u2010old female with RDEB with recurrent aggressive CSCC of the right lateral\u2010back. She was commenced on cemiplimab, an anti\u2010programmed death receptor\u20101 (PD\u20101) antibody, for the management of unresectable locally advanced CSCC; however, she experienced a severe infusion reaction, manifested as back pain, requiring treatment cessation. Despite three incomplete doses, the patient demonstrated a marked response with significant regression of her tumours. Therefore, further treatment was pursued. She was successfully administered cemiplimab under intravenous sedation. This was later complicated by immune\u2010related colitis, necessitating treatment cessation. The patient was transitioned to best supportive care. The patient required inpatient admission for end\u2010of\u2010life care due to her complex analgesia requirements. This case report explores the pathophysiological mechanisms of pain in RDEB and anti\u2010PD\u20101 antibody therapy and highlights the unique challenges of pain management in RDEB patients.<\/jats:p>","DOI":"10.1155\/crdm\/4558623","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:40:21Z","timestamp":1741686021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Infusion Pain Reaction Due to Anti\u2010PD\u20101 Antibodies for the Treatment of Cutaneous Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-5483","authenticated-orcid":false,"given":"Vanessa","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-9943","authenticated-orcid":false,"given":"Susan J.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7142-8288","authenticated-orcid":false,"given":"Jamie","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2598-1397","authenticated-orcid":false,"given":"Malcolm","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alesha A.","family":"Thai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225707"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3875"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.035"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14104"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000775"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1805131"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000508933"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-238966"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2022.105403"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.12.026"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4571"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01811-7"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01428.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx069"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000002130"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2011\/14\/145"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15220"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.34"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1993.tb07599.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02177.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200106000-00022"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/4558623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdm\/4558623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/4558623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:54:28Z","timestamp":1772981668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdm\/4558623"}},"subtitle":[],"editor":[{"given":"Ioannis D.","family":"Bassukas","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdm\/4558623"],"URL":"https:\/\/doi.org\/10.1155\/crdm\/4558623","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4558623"}}