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BRP is a neuropathic pruritus affecting the lateral forearm, whereas MA presents as hyperpigmented patches caused by amyloid deposition in the dermis. We report the first case of synchronous MA and BRP in a 45\u2010year\u2010old woman who presented with severe pruritus in the brachioradialis distribution, concurrent with hyperpigmented patches characteristic of MA. Cervical spine imaging revealed moderate\u2010to\u2010severe multilevel degenerative changes. The patient was successfully treated with gabapentin 200\u2009mg daily, with significant improvement in both conditions. This case highlights the first reported synchronous presentation of MA and BRP and suggests potential shared pathophysiological mechanisms. The favorable dual therapeutic response to gabapentin provides new insights into management strategies for concurrent presentations of these conditions.<\/jats:p>","DOI":"10.1155\/crdm\/5909428","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:35:30Z","timestamp":1764225330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Macular Amyloidosis and Brachioradialis Pruritus Successfully Treated With Gabapentin"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-2330","authenticated-orcid":false,"given":"Hoda","family":"Rahimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-2179","authenticated-orcid":false,"given":"Mehrdad","family":"Ashayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-8111","authenticated-orcid":false,"given":"Roya","family":"Zeinali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-3502","authenticated-orcid":false,"given":"Leila Rezaie","family":"Shirmard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2789"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.026"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.12788\/cutis.0828"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21811"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb03476.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00830.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.2376"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.25251\/skin.3.3.3"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00173-8"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247633"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153059"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16180"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1999.tb00890.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2024.08.028"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb04955.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14857"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5117"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12459"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.170"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.02.005"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18553"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10749.x"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48060"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000524054"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1307412"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.56248"},{"key":"e_1_2_9_27_2","first-page":"268","article-title":"Role of Colchicine in Primary Localised Cutaneous Amyloidosis","volume":"61","author":"Chakravarty K.","year":"1995","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00808.x"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22361"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002994"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02473.x"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1655136"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1654071"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_55_23"},{"key":"e_1_2_9_35_2","first-page":"61","article-title":"Macular Amyloidosis: Treatment with Ultraviolet B","volume":"38","author":"Hudson L. 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