{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:41:19Z","timestamp":1792478479768,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":291,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>As cosmetic procedures gain popularity, the use of nonapproved soft\u2010tissue fillers by unlicensed or untrained practitioners in nonmedical settings is rising. We report a rare case of a histiocytic reaction to foreign material following Argiform injection. A 31\u2010year\u2010old female presented with a 2\u2009year history of an itchy and painful rash on both buttocks. The rash was initially confined to the right buttock but extended to the left several months later; it remained refractory to topical ointments. A skin punch biopsy revealed extensive adipocytic\u2010like cells within the dermis, some of which mimicked lipoblasts. Immunohistochemistry showed the lesional cells were positive for CD68 and negative for S100 and pancytokeratin. A final diagnosis of a histiocytic reaction to foreign material was made. Following the biopsy results, the patient disclosed a history of cosmetic Argiform injections at a spa 4\u20105\u2009years prior to presentation. This case demonstrates that delayed tissue reactions to Argiform can mimic lipomatous tumors, creating a significant diagnostic pitfall. Clinicopathologic correlation, including a thorough remote medical history, is critical for achieving an accurate diagnosis.<\/jats:p>","DOI":"10.1155\/crdm\/7330965","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:14:26Z","timestamp":1792476866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed Histiocytic Foreign Body Reaction and Granuloma Formation Following Argiform Injection for Soft Tissue Augmentation Mimicking a Lipomatous Tumor on Histopathology: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9607-683X","authenticated-orcid":false,"given":"Mokhtar H.","family":"Abdelhammed","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston 77030 Texas USA  bcm.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois M.","family":"Dodson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston 77030 Texas USA  bcm.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Hafeez","family":"Diwan","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston 77030 Texas USA  bcm.edu"},{"name":"Department of Dermatology Baylor College of Medicine  Houston 77030 Texas USA  bcm.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4073-8443","authenticated-orcid":false,"given":"Ya","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston 77030 Texas USA  bcm.edu"},{"name":"Department of Pathology &amp; Laboratory Medicine Harris Health System Ben Taub Hospital  Houston 77030 Texas USA"},{"name":"Department of Surgery Pathology Service HCA Houston Healthcare Clear Lake  Webster 77598 Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.064"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00853.x"},{"key":"e_1_2_10_3_2","volume-title":"FDA Approved Dermal Fillers","author":"U.S. Food and Drug Administration"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-003-3022-1"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2004.09.005"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12374"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-004-0113-6"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0b013e3181ead122"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.01041.x"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12311"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00059.x"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2017.02.001"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000000468"},{"key":"e_1_2_10_14_2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1468-3083.2007.02354.x","article-title":"Delayed Immune Mediated Adverse Effects Related to Hyaluronic Acid and Acrylic Hydrogel Dermal Fillers: Clinical Findings, Long Term Follow Up and Review of the Literature","volume":"22","author":"Alijotas Reig J.","year":"2008","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07482.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313025.2010.508742"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.2.232"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/7330965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdm\/7330965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/7330965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:14:28Z","timestamp":1792476868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdm\/7330965"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdm\/7330965"],"URL":"https:\/\/doi.org\/10.1155\/crdm\/7330965","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7330965"}}