{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:15:34Z","timestamp":1772993734349,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":221,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Facial pigmentation disorders such as ephelides (commonly known as freckles) and solar lentigines are chronic dermatological conditions associated with sun exposure that can impact cosmetic appearance. This case report presents low\u2010level laser therapy (LLLT) as an effective intervention for two different pigmentary disorders in Syrian women: one with ephelides and another with solar lentigines. The first case involved a 34\u2010year\u2010old woman with Fitzpatrick skin type II presenting with facial ephelides, while the second case featured a 49\u2010year\u2010old woman with Fitzpatrick skin type III diagnosed with solar lentigo. Both patients underwent 12 sessions from June 1 to August 1, 2023, using a red diode laser (660\u2009nm) at a power density of 15.6\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    and a dose of 5.6\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , applied for 6\u2009min per session, with one pass per treatment area. The results demonstrated a marked reduction in pigmentation intensity and lesion size, with no reported side effects or lesion recurrence during a 1\u2010year follow\u2010up. These results suggest that LLLT may serve as an effective and safe therapeutic modality for selected facial pigmentary disorders.\n                  <\/jats:p>","DOI":"10.1155\/crdm\/8197442","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T06:18:44Z","timestamp":1754893124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Level Laser Therapy as an Effective Intervention for Facial Pigmentation: A Case Report of Ephelides and Lentigines in Syrian Women"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-832X","authenticated-orcid":false,"given":"Kawthar","family":"Shurrab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Nabil","family":"Alzghayar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,10]]},"reference":[{"key":"e_1_2_13_1_2","first-page":"41","article-title":"Low-Level Laser (Light) Therapy (LLLT) in Skin: Stimulating, Healing, Restoring","volume":"32","author":"Avci P.","year":"2013","journal-title":"Seminars in Cutaneous Medicine and Surgery"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.optlaseng.2025.109129"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.12864"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.09.017"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12841"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2020.35"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.jbo.21.8.088001"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/photonics9080591"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22791"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0454-7"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16404"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.6.457"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00131.x"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12232"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700372"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09152.x"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20412"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12935"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.08.003"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.2041330"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/8197442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdm\/8197442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/8197442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:54:13Z","timestamp":1772981653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdm\/8197442"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdm\/8197442"],"URL":"https:\/\/doi.org\/10.1155\/crdm\/8197442","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8197442"}}