{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:45:41Z","timestamp":1770702341038,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017559","name":"Recordati Rare Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mycosis fungoides (MF) is a subtype of T\u2010cell lymphoma that is characterised by the infiltration of malignant T cells into the skin. Treatment approaches usually include skin\u2010directed therapies for early\u2010stage disease and, additionally, systemic therapies for advanced stages. Chlormethine hydrochloride gel is recommended as a first\u2010line treatment option for adult patients with MF, with previous studies demonstrating its efficacy. Due to the rarity of this disease, available literature on the optimal treatment of MF with chlormethine gel is limited, creating challenges for making informed clinical decisions. Thus, we share our individual clinical experiences of selected patients on chlormethine combination treatments to increase the real\u2010world evidence for chlormethine gel in patients with MF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We present the cases of five male and two female Caucasian patients above the age of 48 with Stage I\u2013IV MF, presenting with symptoms of skin plaques and lesions. All patients were treated with chlormethine hydrochloride gel in combination with other skin\u2010directed and systemic therapies, including bexarotene, methotrexate, topical steroids, extracorporeal photopheresis, donor lymphocyte infusion and interferon\u2010\u03b1 (IFN\u2010\u03b1) 2a. In most cases, chlormethine combination treatment resulted in disease control, e.g., plaque reduction, stable disease, and partial or complete response. The combination regimens were generally well tolerated, with associated adverse events being inflammation, pruritus and erythema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case series reports on the efficacy and safety of chlormethine hydrochloride gel in combination with other topical and systemic therapies in reducing the skin lesion severity in patients with Stage I\u2013IV MF in different real\u2010world settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crdm\/8813008","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:51:47Z","timestamp":1770637907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Mycosis Fungoides With Chlormethine Hydrochloride Gel in Combination With Systemic Therapies: A Case Series"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2544-7197","authenticated-orcid":false,"given":"Gabor","family":"Dobos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanze","family":"Jonak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Christian","family":"Klespe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-2554","authenticated-orcid":false,"given":"Marion","family":"Wobser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e8le","family":"de Masson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-3216","authenticated-orcid":false,"given":"Johanna","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0971-0370","authenticated-orcid":false,"given":"Christina","family":"Mitteldorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19644"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-015-0247-2"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2019.01.004"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0022"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14688"},{"key":"e_1_2_11_6_2","article-title":"EORTC Consensus Recommendations for the Treatment of Mycosis Fungoides\/S\u00e9zary Syndrome \u2013 Update 2023","author":"Latzka J.","year":"2023","journal-title":"European Journal of Cancer"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01721-x"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3171"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18089"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3911"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12059.x"},{"key":"e_1_2_11_12_2","unstructured":"Ledaga\u00ae Summary of Product Characteristics."},{"key":"e_1_2_11_13_2","unstructured":"VALCHLOR (Mechlorethamine) Gel US Prescribing 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