{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:37:54Z","timestamp":1792291074464,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Hair shaft abnormalities, often linked to genetic or acquired conditions, present significant treatment challenges with limited and inconsistent therapeutic success. This report describes an eight\u2010year\u2010old female with severe hair shaft abnormality, unresponsive to standard treatments, including topical minoxidil and platelet\u2010rich plasma therapy, who demonstrated marked improvement following a single session of adipose tissue (AT)\u2013derived exosome therapy. The exosomes were administered via intradermal scalp injections, resulting in significant enhancement in hair structure, strength, and growth within 3\u2009months, with no adverse effects observed. AT\u2010derived exosomes, leveraging mechanisms such as Wnt\/\u03b2\u2010catenin activation and vascular endothelial growth factor expression, hold substantial promise for promoting hair follicle regeneration. This case highlights the potential of exosome therapy as an innovative and effective treatment for hair shaft abnormalities, emphasizing the need for further clinical studies to validate its efficacy and safety.<\/jats:p>","DOI":"10.1155\/crdm\/8838962","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:03:34Z","timestamp":1757581414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regenerative Potential of Adipose Tissue\u2013Derived Exosomes in Treating Hair Shaft Abnormalities: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-8039","authenticated-orcid":false,"given":"Mohammad Ali","family":"Nilforoushzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-8814","authenticated-orcid":false,"given":"Amirhossein","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-4926","authenticated-orcid":false,"given":"Nazila","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-1980","authenticated-orcid":false,"given":"Niloufar Najar","family":"Nobari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085582"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_7_22"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04768.x"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12894"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.04.067"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2024.10.001"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15011647"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122915"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.12099"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15008"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147794"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100048"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000006021"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/life15020141"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.22074\/cellj.2021.7352"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13864"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16683"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/8838962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crdm\/8838962","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/8838962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:54:27Z","timestamp":1772981667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdm\/8838962"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crdm\/8838962"],"URL":"https:\/\/doi.org\/10.1155\/crdm\/8838962","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8838962"}}