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The patients were Japanese males, aged 49 and 52\u2009years, with severe atopic dermatitis, who had been treated with oral cyclosporine for several years. Patch testing revealed that only coco betaine 1% aq. showed a clearly positive reaction in both cases, whereas the patch test results of CP shampoo, cocamidopropyl betaine, and lauramidopropyl betaine were positive in one case and doubtful in the other. In cases of recalcitrant scalp dermatitis, it is necessary to consider the possibility that it is being caused by the topical medication used to treat it, and that the \u201cactive\u201d ingredient may not be the culprit.<\/jats:p>","DOI":"10.1155\/crdm\/9953943","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:46:31Z","timestamp":1767426391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two Cases of Allergic Contact Dermatitis Caused by Coco Betaine in Clobetasol Propionate Shampoo"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-7064","authenticated-orcid":false,"given":"Shigeruko","family":"Iijima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-3006","authenticated-orcid":false,"given":"Kayoko","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.4651"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04348.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14536"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00754.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02464.x"},{"key":"e_1_2_7_6_2","volume-title":"Manual of Contact Dermatitis","author":"Fregert S.","year":"1981"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1091581818773354"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1091581812447202"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0285"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14526"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15149"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000837"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15628"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.001"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.06.048"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12711"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14393"},{"key":"e_1_2_7_18_2","unstructured":"https:\/\/www.cosmetic-info.jp."}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crdm\/9953943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:46:32Z","timestamp":1767426392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crdm\/9953943"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crdm\/9953943"],"URL":"https:\/\/doi.org\/10.1155\/crdm\/9953943","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9953943"}}