{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T20:39:30Z","timestamp":1768595970320,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>SMARCA4\u2010deficient undifferentiated malignant neoplasms (SD\u2010UMNs) are a recently recognized group of malignant epithelioid tumors, associated with mutations in the SWItch\/Sucrose nonfermentable chromatin remodeling complex. To our knowledge, there have been only three cases of SD\u2010UMNs primary to the skin. We report a rare case of primary cutaneous SD\u2010UMN in an 85\u2010year\u2010old male with a former 25\u2010pack\u2010year smoking history. Unlike previous cases, he notably was diagnosed as Stage IV upon presentation, with metastatic involvement of lymph nodes and liver. Our case highlights the importance of recognizing SD\u2010UMN from other types of poorly differentiated cutaneous epithelioid malignant neoplasms, given its aggressive nature and potential for targeted therapies. It also adds to the growing but still limited understanding of the clinical and histopathological features of this rare malignancy.<\/jats:p>","DOI":"10.1155\/crdm\/9982655","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:48:22Z","timestamp":1768556902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage IV SMARCA4\u2010Deficient Undifferentiated Malignant Neoplasm With Primary Cutaneous Origin and Early Distant Metastases"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4280-6045","authenticated-orcid":false,"given":"Katlyn M.","family":"Smaha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-3539","authenticated-orcid":false,"given":"Matthew","family":"Willett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01152-1"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2928"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000475"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.61"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2628"},{"key":"e_1_2_8_6_2","first-page":"6171","article-title":"BRG1, a Component of the SWI-SNF Complex, is Mutated in Multiple Human Tumor Cell Lines","volume":"60","author":"Wong A. 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