{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:37:00Z","timestamp":1772995020899,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":163,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>We present the case of a 39\u2010year\u2010old woman with a history of severe ulcerative colitis (UC) that was refractory to 5\u2010aminosalicylates, corticosteroids, and biologics, and who subsequently underwent total colectomy with ileal pouch\u2013anal anastomosis (IPAA). She developed chronic antibiotic\u2010refractory pouchitis (CARP) characterized by recurrent abdominal pain, cramping, and diarrhea unresponsive to standard treatments. A comprehensive workup, including testing for anti\u2010tissue transglutaminase IgA antibodies, led to the diagnosis of de novo celiac disease, confirmed by endoscopic and histopathologic findings. Initiation of a gluten\u2010free diet resulted in the resolution of symptoms, with no relapse observed during a 9\u2010month follow\u2010up. Our case highlights the importance of considering secondary etiologies such as celiac disease in patients with chronic refractory pouchitis and emphasizes the need for tailored management strategies.<\/jats:p>","DOI":"10.1155\/crgm\/2060709","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T02:49:16Z","timestamp":1749869356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Pouchitis Uncovering De Novo Celiac Disease"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8260-757X","authenticated-orcid":false,"given":"Chakib","family":"Khoury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1893-709X","authenticated-orcid":false,"given":"Rebal","family":"Nahas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6818-5366","authenticated-orcid":false,"given":"Emanuel Youssef","family":"Dib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1914-320X","authenticated-orcid":false,"given":"Karam","family":"Karam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-9098","authenticated-orcid":false,"given":"Elias","family":"Fiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01648445"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.11.006"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90832-x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20791"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0011-3840(77)80065-8"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S306039"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010136"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.530"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28017"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301957"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00553.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.01.001"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(03)00325-1"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.2.234"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.91"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-26"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9370"},{"key":"e_1_2_9_18_2","unstructured":"ShenB. KochharG. S. RubinD. T.et al. Treatment of pouchitis."},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/2060709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crgm\/2060709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/2060709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:27:47Z","timestamp":1772983667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crgm\/2060709"}},"subtitle":[],"editor":[{"given":"Yoshifumi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crgm\/2060709"],"URL":"https:\/\/doi.org\/10.1155\/crgm\/2060709","archive":["Portico"],"relation":{},"ISSN":["2090-6528","2090-6536"],"issn-type":[{"value":"2090-6528","type":"print"},{"value":"2090-6536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2060709"}}