{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:33:32Z","timestamp":1784043212795,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":168,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>The relationship between the human immunodeficiency virus (HIV) and inflammatory bowel disease (IBD) is poorly understood. The coexistence of the two conditions is uncommon with scattered retrospective studies in the literature. Whereas HIV was initially thought to propagate IBD flares and increase disease severity, more studies are coming out showing that HIV may actually be protective against IBD development and relapse, particularly due to the depletion of CD4 lymphocytes. We present a HIV\u2010positive female with new onset ulcerative colitis at the age of 42. Her HIV was poorly controlled for 25\u2009years but with new gastrointestinal symptoms for 9\u2009months, an endoscopic evaluation was done which revealed a new inflammatory bowel disease diagnosis, which warranted immediate therapy. In describing this patient\u2019s case, we discuss the uncommon coexistence of HIV and IBD and investigate potential relationships between the two conditions.<\/jats:p>","DOI":"10.1155\/crgm\/2362039","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T21:48:41Z","timestamp":1750283321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of Ulcerative Colitis in a Patient With Human Immunodeficiency Virus"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-0053","authenticated-orcid":false,"given":"Clive Jude","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad Hayatt","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-7140","authenticated-orcid":false,"given":"Nariman","family":"Hossein-Javaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-5589","authenticated-orcid":false,"given":"Farhan","family":"Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellus Anthony","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navpreet Kaur","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakul Anush","family":"Ravish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Christopher","family":"Mahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-008-0104-x"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21077"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02939.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jve.2021.100033"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/656722"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007357"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz423"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199607000-00008"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000000891"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209815"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000001603"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05500-x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.08.003"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199606000-00015"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(88)80094-5"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018883112012"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570162x19666210611145635"},{"key":"e_1_2_8_18_2","unstructured":"ShaikhA. PatelP. HuynhJ. andPatelP. The Effects of HIV Status on Complications and Outcomes in Patients with Inflammatory Bowel Disease: An Analysis Using the Nationwide Inpatient Sample Database Proceedings from the ACG 2019 Annual Scientific Meeting and Postgraduate Course October 2019."},{"key":"e_1_2_8_19_2","first-page":"337","article-title":"CD4 Count Remission Hypothesis in Patients with Inflammatory Bowel Disease and Human Immunodeficiency Virus Infection: a Systematic Review of the Literature","volume":"28","author":"Skamnelos A.","year":"2015","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0000897604.04797.a2"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/2362039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crgm\/2362039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/2362039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:27:42Z","timestamp":1772983662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crgm\/2362039"}},"subtitle":[],"editor":[{"given":"Poulami","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crgm\/2362039"],"URL":"https:\/\/doi.org\/10.1155\/crgm\/2362039","archive":["Portico"],"relation":{},"ISSN":["2090-6528","2090-6536"],"issn-type":[{"value":"2090-6528","type":"print"},{"value":"2090-6536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2362039"}}