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Case Report: We report a 46\u2010year\u2010old female patient presenting with recurrent abdominal pain and IPO, ultimately diagnosed with SLE through multidisciplinary assessment. The patient exhibited positive antinuclear antibodies (ANAs) (+\u2191), homogeneous karyotype (+++ 1:1000\u2191), low complementemia, and lupus nephritis, meeting the diagnostic criteria for SLE. Abdominal CT showed small intestine and colon wall edema with characteristic \u201ctarget sign\u201d and mesenteric vascular congestion (\u201ccomb\u2010like sign\u201d). Initial treatment included pulse therapy with methylprednisolone (240\u2009mg\/day) combined with cyclophosphamide and hydroxychloroquine, with symptom relief, but recurrence occurred multiple times during the tapering period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature Review<\/jats:title>\n                    <jats:p>Analysis of 54 cases of SLE\u2010related IPO (1997\u20102025) indicated:demographic characteristics: 92.6% were female, and the median age at diagnosis was 31 years. Clinical features: 81.3% of patients presented with abdominal pain; 93.0% involved the small intestine. Imaging examinations: intestinal wall edema (\u201ctarget sign\u201d) and mesenteric vascular hyperplasia (\u201ccomb\u2010like sign\u201d); these signs indicate SLE\u2010related small bowel involvement. Immunological examinations: the positive rate of ANAs (ANA) was 75.9%, the positive rate of anti\u2013double\u2010stranded DNA antibody (anti\u2010dsDNA) was 61.1%, and the positive rate of anti\u2010SSA antibody was 42.5%. Prognosis: Despite immunosuppressive treatment, the recurrence rate was 25%; the mortality rate was 7.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients with recurrent IPO accompanied by low albuminemia, elevated D\u2010dimer, and positive autoantibodies, autoimmune etiology must be considered. Early identification and immunosuppressive treatment are crucial to avoiding unnecessary surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crgm\/3428538","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:03:48Z","timestamp":1785233028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Diagnosis and Treatment of Active Lupus Enteritis Accompanied by Intestinal Pseudo\u2010Obstruction as the Initial Manifestation: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"given":"Wenhan","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-8229","authenticated-orcid":false,"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-2841","authenticated-orcid":false,"given":"Jiyong","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-1695","authenticated-orcid":false,"given":"Wensheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-2682","authenticated-orcid":false,"given":"Chenjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2015.13.3.282"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1212330"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2147\/OARRR.S167783","article-title":"Sjogren\u2019s syndrome and Systemic Lupus Erythematosus: Links and Risks","volume":"11","author":"Pasoto S. 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