{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:22:16Z","timestamp":1787235736842,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":108,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgG4\u2010related disease (IgG4\u2010RD) can involve the liver and pancreas and may present without conventional autoimmune hepatitis (AIH) autoantibodies, creating diagnostic delay unless IgG4 testing and tissue immunostaining are pursued. We describe an older man with acute hepatocellular injury and marked hyperbilirubinemia who was negative for antinuclear (ANA) and antismooth muscle (ASMA) antibodies but had markedly elevated serum IgG4 and IgG4\u2010positive plasma cell infiltration on liver biopsy, consistent with IgG4\u2010related autoimmune hepatitis (IgG4\u2010AIH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A man in his 80s presented with abdominal pain followed by progressive jaundice and pruritus, with acute hepatocellular injury and hyperbilirubinemia. Evaluation showed negative ANA and ASMA, elevated total IgG (2166\u2009mg\/dL) and IgG4 (442.5\u2009mg\/dL), CA 19\u20109 1268 U\/mL, and CT\/MRCP findings consistent with pancreatitis without biliary obstruction or mass. HFE analysis showed compound heterozygosity. Liver biopsy demonstrated interface hepatitis with plasma cell\u2013rich inflammation and increased IgG4\u2010positive plasma cells (up to 58 per high\u2010power field), supporting IgG4\u2010AIH. Minimal iron deposition on biopsy favored inflammation\u2010related iron study abnormalities rather than primary hemochromatosis. The pancreatic findings were most consistent with probable Type 1 autoimmune pancreatitis. Prednisone 40\u2009mg daily led to improvement, with normalization of transaminases and total bilirubin by Day 57 (approximately 8\u2009weeks) in available follow\u2010up testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IgG4\u2010AIH is diagnostically challenging, particularly in seronegative presentations. Unexpectedly high CA 19\u20109 may be seen in IgG4\u2010RD, which may mimic malignancy. In atypical presentations such as those occurring in older adults without conventional antibody positivity or with concurrent pancreatitis on imaging, clinicians should promptly consider early biopsy with immunostaining to avoid diagnostic delay and enable timely steroid treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crgm\/3494971","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:27:59Z","timestamp":1776666479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Markedly Elevated CA 19\u20109 in ANA\/ASMA\u2010Negative IgG4\u2010Related Autoimmune Hepatitis With Concomitant Pancreatitis: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-5437","authenticated-orcid":false,"given":"Hunter","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7197-3803","authenticated-orcid":false,"given":"Samuel","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00768-8"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13683"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez667"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03891-2"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182142fd2"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.005"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000510562"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1859710"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584320"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4687-24"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050408"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.07.007"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.517"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2020.12.032"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-1019-x"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101001"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000344"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i18.2919"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2119758"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.10.020"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174735"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000043359"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/00045632251370803"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051263"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01559-7"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15352"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/3494971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crgm\/3494971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/3494971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:28:00Z","timestamp":1776666480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crgm\/3494971"}},"subtitle":[],"editor":[{"given":"Marcel C. 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