{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:37:33Z","timestamp":1772995053420,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Necrotizing pancreatitis (NP) is characterized by severe pancreatic inflammation with necrosis and a systemic inflammatory response. We describe the case of a 32\u2010year\u2010old female with NP successfully treated with a modified protocol using hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) flushes performed through percutaneous drains (PCDs). She was deemed high risk for endoscopic necrosectomy due to her significant cardiorespiratory comorbidities. As such H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010assisted necrosectomy involving H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    instillation into the necrotic collections via the PCDs was performed. Sequential close clinical follow\u2010up to 1\u2009year showed a durable response without adverse effects. To our knowledge, an extended, durable clinical response has not been previously reported. Further research is required to define clear guidelines on dosing, administration regimen, and follow\u2010up on PCD drainage.\n                  <\/jats:p>","DOI":"10.1155\/crgm\/5520452","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:54:07Z","timestamp":1766991247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogen Peroxide Flushes for Necrotizing Pancreatitis in a High\u2010Risk Surgical Patient: A Pathway for Durable Response Without Additional Endoscopic Intervention"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-7258","authenticated-orcid":false,"given":"Smriti","family":"Kochhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-0852","authenticated-orcid":false,"given":"Ibrahim","family":"Yaghnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6956-155X","authenticated-orcid":false,"given":"Kofi","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.269"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07201-0"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0908821"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2022.11.011"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/den.13699"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000987"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.01.018"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000023175"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.09.007"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/5520452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crgm\/5520452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/5520452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:28:28Z","timestamp":1772983708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crgm\/5520452"}},"subtitle":[],"editor":[{"given":"Marcel Cc","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crgm\/5520452"],"URL":"https:\/\/doi.org\/10.1155\/crgm\/5520452","archive":["Portico"],"relation":{},"ISSN":["2090-6528","2090-6536"],"issn-type":[{"value":"2090-6528","type":"print"},{"value":"2090-6536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5520452"}}