{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:53:11Z","timestamp":1791183191171,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":276,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hibernoma is an uncommon benign adipocytic neoplasm showing differentiation toward brown fat. Although it usually occurs in anatomical sites where residual brown adipose tissue persists, retroperitoneal involvement is particularly uncommon, with fewer than 60 cases reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 54\u2010year\u2010old man was found to have a retroperitoneal mass incidentally during a routine physical examination. CT and MRI demonstrated a 15\u2010cm homogeneous fat\u2010containing lesion without radiological evidence of local invasion. Complete surgical excision was performed. Histopathological examination showed univacuolated and multivacuolated adipocytic cells without atypia. The tumor was positive for S\u2010100 and CD10, and fluorescence in situ hybridization showed no MDM2 amplification, supporting the diagnosis of hibernoma. Recovery was uneventful, and the patient was discharged on Postoperative Day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Retroperitoneal hibernoma can be difficult to distinguish radiologically from other lipomatous neoplasms, including atypical lipomatous tumor\/well\u2010differentiated liposarcoma (ALT\/WDL). Diagnosis therefore relies on the integration of morphology with ancillary immunohistochemical and, when indicated, molecular findings. The decision between preoperative core needle biopsy and upfront resection should be individualized according to the radiological differential diagnosis, tumor vascularity and resectability, expected surgical morbidity, and whether tissue confirmation would alter management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hibernoma should be included in the differential diagnosis of retroperitoneal fat\u2010containing masses. Accurate diagnosis is fundamental, as complete surgical excision is curative, with no need for additional treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crgm\/7500074","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:43:10Z","timestamp":1791182590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retroperitoneal Hibernoma Presenting as a Gastrointestinal Surgical Diagnostic Challenge: A Rare Benign Lipomatous Tumor and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-0799","authenticated-orcid":false,"given":"Gilton Marques","family":"Fonseca","sequence":"first","affiliation":[{"name":"Liver Surgery Unit Department of Gastroenterology University of Sao Paulo Medical School  Sao Paulo Brazil  usp.br"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-358X","authenticated-orcid":false,"given":"Luiz Guilherme Cernaglia Aureliano de","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Sirio-Libanes  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-1635","authenticated-orcid":false,"given":"Marcel Cerqueira Cesar","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Sao Paulo Medical School  Sao Paulo Brazil  usp.br"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2011.e126"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2013.07.006"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cireng.2018.10.004"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjx250"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.90686"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896916653213"},{"key":"e_1_2_11_7_2","first-page":"189","article-title":"Kidney Hibernoma: Case Report and Literature Review","volume":"82","author":"Delsignore A.","year":"2010","journal-title":"Archivio Italiano di Urologia, Andrologia"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.5152\/j.aott.2020.01.445"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910580408"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001061"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231167511"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.31487\/j.SCR.2021.05.07"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00014"},{"key":"e_1_2_11_14_2","first-page":"210","article-title":"US and CT Findings of Hibernoma in an Unusual Location","volume":"18","author":"Yavuz A.","year":"2013","journal-title":"Eastern Journal of Medicine"}],"container-title":["Case Reports in Gastrointestinal 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