{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:42:34Z","timestamp":1792492954473,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":292,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastritis cystica profunda (GCP) is an uncommon gastric lesion characterized by displacement of cystically dilated glands into the submucosa. It may present as a submucosal mass mimicking gastrointestinal stromal tumor (GIST). The coexistence of GCP with high\u2010grade dysplasia is extremely uncommon and may pose a significant diagnostic challenge by simulating invasive carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report a case of a 54\u2010year\u2010old patient whose endoscopic and radiographic features suggested a GIST in the gastric cardia. Surgical resection was performed. Histopathological examination revealed cystically dilated glands extending into the submucosa, lined by high\u2010grade dysplastic epithelium. Importantly, the muscularis mucosae was focally disrupted, and the submucosal component comprised both dysplastic and nondysplastic glands displaced together within smooth muscle bundles derived from the muscularis mucosae and accompanied by lamina propria\u2010type stroma, supporting mucosal prolapse rather than true invasion. A final diagnosis of high\u2010grade dysplasia arising in GCP was established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights an important diagnostic pitfall in distinguishing pseudoinvasion from true invasive carcinoma in submucosal gastric lesions. Recognition of this entity and careful assessment of the muscularis mucosae together with the character of the displaced glands are essential to avoid overstaging and unnecessary aggressive management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crgm\/7741186","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:28:16Z","timestamp":1792492096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastritis Cystica Profunda With High\u2010Grade Dysplasia Mimicking Gastrointestinal Stromal Tumor: A Histopathological Pitfall in the Assessment of Submucosal Invasion"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7115-0477","authenticated-orcid":false,"given":"Vy Thi-Thuy","family":"Duong","sequence":"first","affiliation":[{"name":"Department of Pathology University Medical Center Ho Chi Minh City  Ho Chi Minh City 700000 Vietnam  bvdaihoc.com.vn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6726-5638","authenticated-orcid":false,"given":"Anh The","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Histology Embryology, and Pathology School of Medicine University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City 700000 Vietnam  hcmut.edu.vn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-7062","authenticated-orcid":false,"given":"Tho Ngoc-Quynh","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Ho Chi Minh City  Ho Chi Minh City 700000 Vietnam  bvdaihoc.com.vn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5899-525X","authenticated-orcid":false,"given":"Huyen Thi Thanh","family":"Le","sequence":"additional","affiliation":[{"name":"Independent Researcher  Ho Chi Minh City 700000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-4602","authenticated-orcid":false,"given":"Giang Huong","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Histology Embryology, and Pathology School of Medicine University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City 700000 Vietnam  hcmut.edu.vn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_12_1_2","first-page":"628","volume-title":"Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas","author":"Clauditz T.","year":"2023"},{"key":"e_1_2_12_2_2","volume-title":"WHO Classification of Tumours Editorial Board. 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