{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T21:08:32Z","timestamp":1784408912020,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Sulfasalazine, a commonly prescribed medication for treating ulcerative colitis, can cause a severe yet rare adverse drug reaction known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. In this case, a female patient experienced a severe flare of her ulcerative colitis, accompanied by sulfasalazine\u2010induced DRESS syndrome. The ulcerative colitis flare and acute liver injury resolved with a treatment regimen of high\u2010dose steroids and cyclosporine. However, she continued to have treatment\u2010resistant dermatologic changes and delayed organ involvement, including the development of hyperthyroidism that required close multidisciplinary follow\u2010up. IVIG was used to successfully wean steroids and cyclosporine after a year of therapy.<\/jats:p>","DOI":"10.1155\/crgm\/8870613","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T04:03:46Z","timestamp":1749873826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Following Initiation of Sulfasalazine for Ulcerative Colitis: A Yearlong Clinical Challenge"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-4769","authenticated-orcid":false,"given":"Michael B.","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-794X","authenticated-orcid":false,"given":"Michael V.","family":"Patrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-6470","authenticated-orcid":false,"given":"Stephen J.","family":"Bickston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.08.013"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_582_17"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.4519"},{"key":"e_1_2_11_4_2","first-page":"31","article-title":"Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome","volume":"6","author":"Choudhary S.","year":"2013","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2023.100850"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100673"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.03.002"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184287"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15196"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102143"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1371490"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030739"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/8870613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crgm\/8870613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crgm\/8870613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:28:25Z","timestamp":1772983705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crgm\/8870613"}},"subtitle":[],"editor":[{"given":"Poulami","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crgm\/8870613"],"URL":"https:\/\/doi.org\/10.1155\/crgm\/8870613","archive":["Portico"],"relation":{},"ISSN":["2090-6528","2090-6536"],"issn-type":[{"value":"2090-6528","type":"print"},{"value":"2090-6536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8870613"}}