{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:04:37Z","timestamp":1779685477109,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":143,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001249","name":"University of Tasmania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Amiodarone is a widely prescribed antiarrhythmic drug, but it can rarely cause severe progressive hepatotoxicity. This report presents a 74\u2010year\u2010old man on long\u2010term amiodarone therapy who developed tense ascites and cholestatic liver dysfunction after 12\u2009years of continuous treatment, corresponding to a cumulative dose of 876\u2009g. Five months prior to presentation, routine liver tests showed subtle and nonspecific abnormalities in liver enzymes, and there were no clinical stigmata of chronic liver disease. Quad\u2010phase CT imaging demonstrated features of chronic liver disease, with increased hepatic attenuation on the noncontrast phase, consistent with iodine deposition in the context of long\u2010term amiodarone exposure. Liver biopsy confirmed cirrhosis with ballooning hepatocytes, Mallory\u2013Denk bodies, and neutrophilic satellitosis in the absence of steatosis, histological features suggestive of amiodarone\u2010induced liver injury. Secondary causes were excluded. Despite discontinuation of amiodarone and initiation of supportive therapy, the patient experienced recurrent decompensation. This case underscores the potential for subclinical progression of amiodarone\u2010induced liver injury, even in the presence of subtle or nonspecific abnormalities in liver biochemistry without a clear pattern to predict advanced fibrosis or imminent decompensation. Increased hepatic density on noncontrast CT imaging may serve as a radiologic indicator of drug deposition. Long\u2010term vigilance and monitoring of cumulative dose are essential for early detection and prevention of irreversible liver injury.<\/jats:p>","DOI":"10.1155\/crgm\/9933788","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:01:05Z","timestamp":1779685265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Smoldering Amiodarone\u2010Induced Decompensated Cirrhosis: Cumulative Dose\u2013Related Toxicity"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9170-5135","authenticated-orcid":false,"given":"Jason","family":"Ta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-4084","authenticated-orcid":false,"given":"Ritesh","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Di Francesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Chhabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1839-4330","authenticated-orcid":false,"given":"Junaid","family":"Beig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.006"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02837-9"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2023.02.012"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqab142"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090504"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90076-h"},{"key":"e_1_2_10_7_2","first-page":"81","article-title":"Hepatic Effects of Amiodarone","volume":"44","author":"Adams P. C.","year":"1986","journal-title":"British Journal of Clinical Practice Supplement"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(86)80031-9"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2015.23"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i34.5394"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240011"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198409020-00002"},{"key":"e_1_2_10_13_2","volume-title":"Amiodarone-Induced Cirrhosis of Liver: What Predicts Mortality? 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