{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:00:40Z","timestamp":1791198040220,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":277,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    A 65\u2010year\u2010old man presenting with pancytopenia and circulating large atypical cells was initially suspected of having acute leukemia. Flow cytometric analysis demonstrated a mature clonal B\u2010cell phenotype, and the integrated findings supported a diagnosis of a CD5\u2010positive mature B\u2010cell neoplasm with large\u2010cell morphology, predominant bone marrow involvement, and a leukemic peripheral blood presentation. Based on the available staging data, primary bone marrow DLBCL was suspected but could not be definitively confirmed. The neoplasm was characterized by CD5 expression, a\n                    <jats:italic>BCL6<\/jats:italic>\n                    rearrangement, and a complex karyotype including monosomy 17. The patient received six cycles of R\u2010CHOP followed by two cycles of systemic high\u2010dose methotrexate as individualized central nervous system prophylaxis. A complete response was confirmed after treatment, with no evidence of recurrence 6\u2009months after treatment completion.\n                  <\/jats:p>","DOI":"10.1155\/crh\/1476825","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:17:23Z","timestamp":1791195443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD5\u2010Positive Mature B\u2010Cell Neoplasm With Large\u2010Cell Morphology, Predominant Bone Marrow Involvement, and a Leukemic Peripheral Blood Presentation: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1557-3586","authenticated-orcid":false,"given":"Masamitsu","family":"Takaba","sequence":"first","affiliation":[{"name":"Department of Hematology Seirei Hamamatsu General Hospital  Hamamatsu Japan  seirei.or.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Hematology Seirei Hamamatsu General Hospital  Hamamatsu Japan  seirei.or.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Seirei Hamamatsu General Hospital  Hamamatsu Japan  seirei.or.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1129-4"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2178"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S187522"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq627"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.25732"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2324709620982765"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S384983"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.231076"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2018.05.004"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/1476825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crh\/1476825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/1476825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:17:24Z","timestamp":1791195444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/1476825"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crh\/1476825"],"URL":"https:\/\/doi.org\/10.1155\/crh\/1476825","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1476825"}}