{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:15Z","timestamp":1789456035581,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":256,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple myeloma (MM) frequently causes renal impairment, and a subset of patients progresses to end\u2010stage renal disease (ESRD) requiring dialysis. Dialysis dependence has historically been considered a relative contraindication to high\u2010dose conditioning and autologous stem cell transplantation (ASCT). Emerging evidence indicates that ASCT may provide effective hematologic control and, in selected patients, renal recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective case series of five dialysis\u2010dependent patients with MM who underwent ASCT at An\u2010Najah National University Hospital. Demographic and clinical characteristics, transplant variables, supportive\u2010care measures, infectious and noninfectious complications, hematologic recovery, admission and discharge laboratory values, and short\u2010term outcomes were extracted from the medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The five patients had a mean age of 56\u2009years and received reduced\u2010dose melphalan (140\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), followed by peripheral\u2010blood CD34+ cell infusion. The mean CD34+ collection and infusion doses were 4.3\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/kg and 4.1\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/kg, respectively. All patients achieved engraftment; mean neutrophil and platelet engraftment occurred on Days 13.0 and 19.4, respectively. Four patients (80%) developed neutropenic fever.\n                      <jats:italic>Clostridioides difficile<\/jats:italic>\n                      and\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      were the most frequently documented pathogens. Two patients developed central line\u2013associated bloodstream infection and septic shock. No 100\u2010day treatment\u2010related mortality occurred. Creatinine and blood urea nitrogen remained elevated, and all patients continued maintenance hemodialysis at discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ASCT was feasible in carefully selected dialysis\u2010dependent patients with MM and was associated with timely hematologic recovery and no 100\u2010day treatment\u2010related mortality. Infectious complications and vascular\u2010access management remain major clinical concerns. Larger prospective studies are needed to define long\u2010term renal outcomes and predictors of dialysis independence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crh\/1808249","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:19:01Z","timestamp":1789453141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Outcomes Following Autologous Stem Cell Transplantation in Dialysis\u2010Dependent Patients With Multiple Myeloma: A Single\u2010Center Study From a Low\u2010 and Middle\u2010Income Country"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-8013","authenticated-orcid":false,"given":"Maher","family":"Battat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2701-8854","authenticated-orcid":false,"given":"Ahmad","family":"Khursani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2969-4984","authenticated-orcid":false,"given":"Mohammedkhaled J.","family":"Alhendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1449-879X","authenticated-orcid":false,"given":"Momen","family":"Sawafta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8569-1264","authenticated-orcid":false,"given":"Asa\u2019d A. 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