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We present a 64\u2010year\u2010old man with a significant family history for WM who was found to have both ET and WM. He had symptomatic ET, diagnosed by elevated platelets and a positive JAK2 V617F mutation, and asymptomatic WM was found on serum electrophoresis done for screening due to family history. Genomic evaluation of the myeloid and lymphoid cells suggested independent neoplastic transformation. This is the second reported case of a patient with both WM and ET. There was no evidence for a shared mechanism in these dual malignancies.<\/jats:p>","DOI":"10.1155\/crh\/3390770","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:04:26Z","timestamp":1756379066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of Essential Thrombocythemia and Waldenstr\u00f6m Macroglobulinemia: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"given":"Meghan","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Mathey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6799-2022","authenticated-orcid":false,"given":"Cecilia C. 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