{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:31:04Z","timestamp":1781649064995,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":140,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    We describe a rare case of a brain abscess occurring during CPX\u2010351 induction therapy for acute myeloid leukemia (AML). The patient experienced recurrent febrile neutropenia during the myelosuppression period and developed left\u2010sided spatial neglect during hematologic recovery. Brain magnetic resonance imaging revealed a solitary abscess in the right parietal lobe. Burr hole drainage yielded\n                    <jats:italic>Bacillus<\/jats:italic>\n                    species, and subsequent treatment with vancomycin and linezolid, followed by endoscopic abscess resection, led to gradual neurological recovery. Complete remission of AML was achieved, and consolidation therapy with venetoclax plus azacitidine was initiated. CPX\u2010351 is associated with prolonged myelosuppression and relatively low gastrointestinal toxicity, which may reduce the risk of Gram\u2010negative sepsis but increase susceptibility to Gram\u2010positive infections, such as catheter\u2010related bacteremia. Clinicians should consider the possibility of a brain abscess in patients presenting with neurological symptoms during AML treatment, as early diagnosis and prompt surgical and antimicrobial management are critical for favorable outcomes.\n                  <\/jats:p>","DOI":"10.1155\/crh\/3668400","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:51:17Z","timestamp":1779421877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain Abscess Following CPX\u2010351 Treatment in a Patient With Acute Myeloid Leukemia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5594-4601","authenticated-orcid":false,"given":"Yusuke","family":"Yamaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daimon","family":"Siraisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.77.6112"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003159"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1725503"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.40.654"},{"key":"e_1_2_12_5_2","first-page":"1463","article-title":"Cord Blood Transplantation After Successful Treatment of Brain Abscess Caused by Bacillus Cereus in a Patient With Acute Myeloid Leukemia","volume":"47","author":"Kuwabara H.","year":"2006","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4753-1"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-021-00452-9"},{"key":"e_1_2_12_8_2","article-title":"Mucormycosis Causing Splenic Infarction, Gastric Fistula, and Brain Abscess in a Patient with Acute Myeloid Leukemia: A Case Report","volume":"2024","author":"da Silveira F. 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