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This study evaluated the effectiveness of gilteritinib combined with venetoclax in patients with relapsed\/refractory (R\/R) acute myeloid leukemia (AML) or myelodysplastic neoplasms (MDS) with wild\u2010type\n                    <jats:italic>FLT3<\/jats:italic>\n                    , who currently lack targeted therapy. After a 28\u2010day cycle of venetoclax\u2013gilteritinib therapy, one patient with R\/R AML and other genetic alterations achieved minimal residual disease (MRD)\u2013positive complete remission (CR) with incomplete hematologic recovery (CRi). Another patient with R\/R\n                    <jats:italic>ASXL1<\/jats:italic>\n                    \u2010mutated MDS\/AML achieved morphologic leukemia\u2010free state (MLFS) after one cycle, but cytopenias persisted across two cycles. A patient with R\/R\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated AML related to myelodysplasia did not respond (NR) after two cycles, although the blast percentage in bone marrow (BM) and peripheral blood (PB) decreased by 50%. In a patient with R\/R AML carrying an in\u2010frame bZIP\u2010mutated\n                    <jats:italic>CEBPA<\/jats:italic>\n                    , NR and disease progression occurred after one cycle, but elevated white blood cell (WBC) counts declined after treatment initiation and lasted for 2\u2009weeks. These findings suggest that combining gilteritinib with venetoclax may reduce tumor burden in R\/R AML\/MDS patients with wild\u2010type\n                    <jats:italic>FLT3<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/crh\/4335095","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:29:15Z","timestamp":1761762555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential Off\u2010Target Effect of Gilteritinib With Venetoclax Decreases Tumor Burden for Patients With Relapsed\/Refractory Wild\u2010Type\n                    <i>FLT3<\/i>\n                    Acute Myeloid Leukemia\/Myelodysplastic Neoplasms"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5673-1733","authenticated-orcid":false,"given":"Shuting","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanru","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1773-483X","authenticated-orcid":false,"given":"Xinlei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-3811","authenticated-orcid":false,"given":"Zhiping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1516192"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26984"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.336"},{"key":"e_1_2_12_4_2","first-page":"325","article-title":"A Systematic Literature Review of Disease Burden and Clinical Efficacy for Patients With Relapsed or Refractory Acute Myeloid Leukemia","volume":"11","author":"Oliva E. 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