{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:21:16Z","timestamp":1783524076420,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":334,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Systemic mastocytosis (SM) is a rare hematologic disorder characterized by clonal proliferation of mast cells in the bone marrow and\/or other organs. SM\u2010associated hematologic neoplasm (SM\u2010AHN) is one of the advanced SM variants that usually confer a poor prognosis. We present a case of a 75\u2010year\u2010old female patient with SM\u2010AHN, specifically myelodysplastic syndrome (MDS), that harbored a unique KIT mutation KIT V560D, not previously described in the literature in this setting. We describe the clinical course and the outcome with the use of avapritinib, midostaurin, and decitabine\u2010cedazuridine.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00782067\">NCT00782067<\/jats:ext-link><\/jats:p>","DOI":"10.1155\/crh\/4360304","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T12:35:14Z","timestamp":1732970114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["KIT V560D\u2010Mutated Systemic Mastocytosis Associated With High\u2010Risk Myelodysplastic Syndrome: A Unique Case of Systemic Mastocytosis\u2013Associated Hematologic Neoplasm"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-194X","authenticated-orcid":false,"given":"Georgio","family":"Medawar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Sakalabaktula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Magri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rinker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praneeth","family":"Baratam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.5045\/br.2023.2023024"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-731893"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000646"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23380"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.19080\/ctoij.2023.24.556141"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061664"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-016-0120-8"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26962"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/cpaa.s206615"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00443"},{"key":"e_1_2_11_12_2","unstructured":"Fda 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