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Due to its infectious mimicry, diagnosis is frequently delayed. We report a case of primary myelofibrosis initially treated for suspected cellulitis, which progressed to necrotic lesions and refractory fever despite broad\u2010spectrum antibiotics. A skin biopsy confirmed neutrophilic vasculitis consistent with SS. Prompt treatment with corticosteroids followed by ruxolitinib achieved rapid resolution by suppressing the underlying cytokine storm.<\/jats:p>","DOI":"10.1155\/crh\/4413111","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:05:45Z","timestamp":1775473545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Uncommon Presentation of Sweet\u2019s Syndrome in Primary Myelofibrosis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3711-0094","authenticated-orcid":false,"given":"Valentina","family":"Rago","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9247-5324","authenticated-orcid":false,"given":"Valeria","family":"Brogna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-9476","authenticated-orcid":false,"given":"Fabrizio","family":"Cavalca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8794-984X","authenticated-orcid":false,"given":"Matteo","family":"Faltoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0686-6203","authenticated-orcid":false,"given":"Antonio Maria","family":"Alviano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-515X","authenticated-orcid":false,"given":"Carlo","family":"Gambacorti-Passerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-5412","authenticated-orcid":false,"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13350"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2016.05.021"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02287.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00414"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-228076"},{"key":"e_1_2_10_6_2","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/ajh.27199","article-title":"Persistent Sweet Syndrome Post-Hematopoietic Stem Cell Transplantation Heralding Molecular Relapse of Myelofibrosis","volume":"99","author":"Xiang D. 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