{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:22:06Z","timestamp":1772994126880,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2T32CA217834-07"],"award-info":[{"award-number":["2T32CA217834-07"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>In this case report, we present a patient with severe thrombocytopenia induced by adalimumab after 4\u2009weeks of treatment for rheumatoid arthritis. This case adds to present literature regarding antitumor necrosis factor\u2010alpha (TNF\u2010\u03b1)\u2010induced thrombocytopenia and explores the use of thrombopoietin receptor agonist medications in refractory drug\u2010induced immune thrombocytopenia (DITP). A 57\u2010year\u2010old female with a history of rheumatoid arthritis presented to the emergency department for progressive petechial rash 4\u2009days after her third dose of adalimumab. It was determined that the patient had immune thrombocytopenia caused by adalimumab and was initially treated with steroids and intravenous immunoglobulin (IVIG). Platelets remained undetectable; hence, romiplostim was initiated, after which platelets trended up to normal levels a week later. Anti\u2010TNF\u2010\u03b1 agents carry the risk of severe side effects, including thrombocytopenia, which should be monitored closely in the first few months of therapy. The treatment of DITP is challenging, especially when the causative agent has a prolonged half\u2010life.<\/jats:p>","DOI":"10.1155\/crh\/4414589","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T13:49:53Z","timestamp":1757339393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adalimumab\u2010Induced Thrombocytopenia: A Case Report of Drug\u2010Induced Thrombocytopenia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4273-6426","authenticated-orcid":false,"given":"Shelby E.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7166-0619","authenticated-orcid":false,"given":"Joshua","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret C.","family":"Wheless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9268-7609","authenticated-orcid":false,"given":"Danielle","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7910-7154","authenticated-orcid":false,"given":"Robert K.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14778"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.04.001"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.123547"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14769"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1041884"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16915"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.211086"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03360.x"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002400706"},{"key":"e_1_2_10_10_2","volume-title":"NPLATE (Romiplostim)","year":"2008"},{"key":"e_1_2_10_11_2","volume-title":"Promacta (Eltrombopag)","year":"2008"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/4414589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crh\/4414589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/4414589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:05:28Z","timestamp":1772982328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/4414589"}},"subtitle":[],"editor":[{"given":"Ana","family":"Antun","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crh\/4414589"],"URL":"https:\/\/doi.org\/10.1155\/crh\/4414589","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4414589"}}