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Although hydroxyurea\u2010induced skin ulcers are uncommon, they are a recognized long\u2010term adverse effect. Current management generally recommends discontinuation of hydroxyurea as the mainstay of treatment; however, drug withdrawal may aggravate the underlying hematologic disease. We report a case of bilateral medial malleolar ulcers associated with hydroxyurea therapy in a 65\u2010year\u2010old man with essential thrombocythemia, who showed marked improvement after two months of topical treatment with recombinant bovine basic fibroblast growth factor (rb\u2010bFGF) gel, without discontinuation of hydroxyurea. Complete healing was confirmed at 25\u2010month follow\u2010up, while hematologic disease control was maintained. This case suggests that localized wound care with topical rb\u2010bFGF may represent a feasible therapeutic option in selected patients when hydroxyurea discontinuation is not feasible.<\/jats:p>","DOI":"10.1155\/crh\/5054123","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:30:03Z","timestamp":1784115003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Topical Treatment of Hydroxyurea\u2010Induced Ulcers Without Drug Discontinuation: A Case 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