{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:58Z","timestamp":1787017858395,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":168,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Hypereosinophilia presents a significant clinical challenge. We describe a case of severe, rapidly progressing hypereosinophilia, with the white blood cell count increasing from 40,000\/\u03bcL to over 130,000\/\u03bcL within days, and 70% eosinophils on differential count. The patient initially presented with diffuse symptoms but developed eosinophilic myocarditis during hospitalization. Targeted next\u2010generation sequencing identified a mutation in\n                    <jats:italic>NPM1<\/jats:italic>\n                    and according to the WHO 5\n                    <jats:sup>th<\/jats:sup>\n                    edition criteria, the patient was diagnosed with acute myeloid leukemia (AML) with\n                    <jats:italic>NPM1<\/jats:italic>\n                    mutation. Whole genome and transcriptome sequencing revealed a concurrent fusion\n                    <jats:italic>ETV6<\/jats:italic>\n                    ::\n                    <jats:italic>ACSL6<\/jats:italic>\n                    . This fusion has been previously described in myeloid diseases with eosinophilia. Despite initial deep response to AML treatment, reaching MRD\u2010negativity for\n                    <jats:italic>NPM1<\/jats:italic>\n                    , the patient relapsed shortly after stem cell transplantation and died.\n                  <\/jats:p>","DOI":"10.1155\/crh\/5125740","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T07:20:45Z","timestamp":1750231245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Myeloid Leukemia With\n                    <i>NPM1<\/i>\n                    Mutation Presenting With Rapidly Progressing Hypereosinophilia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-6805","authenticated-orcid":false,"given":"S.","family":"Einarsdottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Orrsj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5026-8195","authenticated-orcid":false,"given":"L.","family":"von Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-7312","authenticated-orcid":false,"given":"A.","family":"Staffas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-8519","authenticated-orcid":false,"given":"L.","family":"Fogelstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.04.002"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00469.x"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-023-02696-4"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12955"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020337"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26352"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2021.12.006"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01478-6"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8324791"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34122"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282255"},{"key":"e_1_2_10_13_2","unstructured":"SwerdlowS. H. C. E. HarrisN. L. JaffeE. S. andPileriS. A. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2017."},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2018.04.001"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/5125740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crh\/5125740","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/5125740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:05:20Z","timestamp":1772982320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/5125740"}},"subtitle":[],"editor":[{"given":"Ha Kon","family":"Reikvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crh\/5125740"],"URL":"https:\/\/doi.org\/10.1155\/crh\/5125740","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5125740"}}